血清铁蛋白水平升高可有效鉴别 2019 冠状病毒病肺炎的严重程度和肝损伤。
Elevated serum ferritin level effectively discriminates severity illness and liver injury of coronavirus disease 2019 pneumonia.
机构信息
Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan, China.
出版信息
Biomarkers. 2021 May;26(3):207-212. doi: 10.1080/1354750X.2020.1861098. Epub 2021 Feb 10.
AIM
Ferritin is a hepatic protein that plays vital roles in diagnosing and predicting diseases, but its potential in coronavirus disease 2019 (COVID-19) remains unknown.
METHOD
We collected clinical records from 79 COVID-19 patients at Wuhan Union hospital (China). Spearman's correlation analysis, receiver operating characteristic (ROC) curve and Kaplan-Meier survival curves were employed.
RESULTS
Patients with elevated ferritin levels had a higher incidence of severity illness (50.0 vs 2.9%) and liver injury (52.3 vs 20.0%) when compared with patients with normal ferritin levels ( < 0.05). Ferritin could effectively identify the severity of illness (ROC area 0.873) and liver injury (ROC area 0.752). The elevated ferritin group showed longer viral clearance time (median 16 vs 6 days, < 0.001) and in-hospital length (median 18 vs 10 days, < 0.001).
CONCLUSIONS
It suggests that ferritin could act as an easy-to-use tool to identify liver injury and severity illness and predict the prognosis of COVID-19 patients. Intensive surveillance is necessary for patients with abnormal ferritin levels.
目的
铁蛋白是一种肝脏蛋白，在诊断和预测疾病方面发挥着重要作用，但它在 2019 年冠状病毒病（COVID-19）中的潜在作用尚不清楚。
方法
我们收集了武汉协和医院（中国）79 名 COVID-19 患者的临床记录。采用 Spearman 相关分析、受试者工作特征（ROC）曲线和 Kaplan-Meier 生存曲线。
结果
与铁蛋白正常（<0.05）的患者相比，铁蛋白升高的患者更易发生严重疾病（50.0%比 2.9%）和肝损伤（52.3%比 20.0%）。铁蛋白可有效识别疾病严重程度（ROC 曲线下面积 0.873）和肝损伤（ROC 曲线下面积 0.752）。铁蛋白升高组的病毒清除时间（中位数 16 比 6 天，<0.001）和住院时间（中位数 18 比 10 天，<0.001）更长。
结论
这表明铁蛋白可作为一种简单易用的工具，用于识别肝损伤和严重疾病，并预测 COVID-19 患者的预后。对于铁蛋白水平异常的患者，需要进行强化监测。
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