哺乳动物内质网-质膜连接的最新见解。
Recent insights into mammalian ER-PM junctions.
机构信息
Department of Physiology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Department of Physiology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Curr Opin Cell Biol. 2019 Apr;57:99-105. doi: 10.1016/j.ceb.2018.12.011. Epub 2019 Feb 8.
Abstract
ER-PM junctions are subcellular sites where the endoplasmic reticulum (ER) and the plasma membrane (PM) are kept in close appositions, providing a platform for inter-organelle contact. These membrane contact sites are important for many physiological functions in mammalian cells, including excitation-contraction coupling, store-operated Ca entry, and non-vesicular transfer of lipids between the ER and the PM. Here we review recent insights into the 3D structure and spatial organization of ER-PM junctions in mammalian cells as well as molecular mechanisms underlying the formation and functions of mammalian ER-PM junctions.
摘要
ER-PM 连接点是内质网 (ER) 和质膜 (PM) 紧密相邻的亚细胞位点，为细胞器之间的接触提供了一个平台。这些膜接触点对于哺乳动物细胞中的许多生理功能非常重要，包括兴奋-收缩偶联、钙库操纵性钙内流以及 ER 和 PM 之间的非囊泡脂质转移。在这里，我们综述了最近关于哺乳动物细胞中 ER-PM 连接点的 3D 结构和空间组织以及哺乳动物 ER-PM 连接点形成和功能的分子机制的研究进展。
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