Yu Fang, Machaca Khaled
Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Doha, Qatar.
Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Contact (Thousand Oaks). 2025 Jan 29;8:25152564241309207. doi: 10.1177/25152564241309207. eCollection 2025 Jan-Dec.
Membrane contact sites (MCS) provide specialized conduits for inter-organelle communications to maintain cellular homeostasis. Most organelles are interconnected, which supports their coordination and function. M-phase (mitosis or meiosis) is associated with dramatic cellular remodeling to support cell division, including the equal distribution of organelles to the two daughter cells. However, the fate of MCS in M-phase is poorly understood. Here we review recent advances arguing for differential remodeling of endoplasmic reticulum (ER) MCS with the plasma membrane (PM, ERPMCS) and the mitochondria (MERCS) during cell division.
膜接触位点（MCS）为细胞器间通讯提供了专门的通道，以维持细胞内稳态。大多数细胞器相互连接，这有助于它们的协调与功能发挥。M期（有丝分裂或减数分裂）与剧烈的细胞重塑相关，以支持细胞分裂，包括细胞器向两个子细胞的均等分配。然而，人们对M期MCS的命运了解甚少。在此，我们综述了近期的研究进展，这些进展表明在细胞分裂过程中，内质网（ER）与质膜（PM，ER-PM MCS）和线粒体（M-ER CS）的MCS存在差异重塑。
