Borison H L, Gonsalves S F, Montgomery S P, McCarthy L E
J Appl Physiol Respir Environ Exerc Physiol. 1978 Oct;45(4):502-11. doi: 10.1152/jappl.1978.45.4.502.
Arterial blood pH (pHa) was continuously monitored in decerebrate or pentobarbital-anesthetized cats with a rapidly responding hydrogen ion sensor inserted into the aorta. Alveolar carbon dioxide partial pressure and pHa were controlled independently during infusions of 1 N NaHCO3 or 0.5 N HCl into the inferior vena cava. Shifts in pHa up to 0.3 unit were effected isocapnically within 2.5-20 s over a working pHa range of 6.9-7.7. Before carotid sinus neurotomy, average onset latency of the tidal volume (VT) response to acid and alkaline pHa shifts was less than 5 S and the average VT response half time was less than 8.5 s regardless of whether the vagus nerves had been interrupted. After carotid sinus neurotomy, the deltaVT onset latency was approximately doubled, whereas the response half time was prolonged about eightfold on the average. Subsequent vagotomy tended further to increase the responding time lag. Nevertheless, the minimum response latency after peripheral chemodenervation was less than the deltapHa forcing rise time. It is concluded that the central chemoreceptors promptly sense pH change in the arterial blood and that neural processes adjust the time course of the respiratory response through the VT controller.
将一个快速响应的氢离子传感器插入主动脉，对去大脑或戊巴比妥麻醉的猫的动脉血pH值（pHa）进行连续监测。在下腔静脉输注1N碳酸氢钠或0.5N盐酸期间，独立控制肺泡二氧化碳分压和pHa。在6.9-7.7的工作pHa范围内，在2.5-20秒内等碳酸条件下实现了高达0.3个单位的pHa变化。在颈动脉窦神经切断术之前，无论迷走神经是否已被切断，潮气量（VT）对酸性和碱性pHa变化的平均起始潜伏期均小于5秒，平均VT反应半衰期小于8.5秒。颈动脉窦神经切断术后，ΔVT起始潜伏期大约增加一倍，而反应半衰期平均延长约八倍。随后的迷走神经切断术往往会进一步增加反应时间延迟。然而，外周化学感受器去神经支配后的最小反应潜伏期小于pHa强迫上升时间。得出的结论是，中枢化学感受器能迅速感知动脉血中的pH变化，并且神经过程通过VT控制器调节呼吸反应的时间进程。
