Borison H L, Hurst J H, McCarthy L E, Rosenstein R
Respir Physiol. 1977 Aug;30(3):311-25. doi: 10.1016/0034-5687(77)90038-x.
Arterial blood hydrogen ion concentration (Ha+) was altered over the range of 25 to 110 nM (pH 7.60 to 6.96) by slow intravenous infusion of 1.0 N NaHCO3 or 0.5 N HC1 at controlled levels of Paco2in unanesthetized decerebrate cats. Respiratory f varied as a single function of Vt irrespective of a lterations in Paco2 and Ha+ even after interruption of the carotid sinus nerves. The dependence of f upon Vt was abolished by vagotomy. However, Vt continued to respond to changes in Ha+ over its entire range after combined section of the vagus and carotid sinus nerves. In all statxceeded by 5 to 10 times the delta Vt/delta Ha+ response to acid or bicarbonate infused under isocapnic control. Increases and decreases of ha+ caused downward and upward shifts, respectively, in the operating setpoint of the CO2 regulation system.
在未麻醉的去大脑猫中，通过以可控的动脉血二氧化碳分压（Paco₂）水平缓慢静脉输注1.0N碳酸氢钠或0.5N盐酸，将动脉血氢离子浓度（Ha⁺）在25至110纳摩尔/升（pH值7.60至6.96）范围内改变。呼吸频率（f）仅作为潮气量（Vt）的单一函数而变化，无论Paco₂和Ha⁺如何改变，即使在切断颈动脉窦神经后也是如此。切断迷走神经后，f对Vt的依赖性消失。然而，在迷走神经和颈动脉窦神经联合切断后，Vt在其整个范围内仍继续对Ha⁺的变化作出反应。在所有状态下，等碳酸控制下输注酸或碳酸氢盐时，Vt/Ha⁺的变化反应比其大5至10倍。Ha⁺的增加和减少分别导致二氧化碳调节系统的工作设定点向下和向上移动。
