Division of Neurology, Comprehensive Epilepsy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Epilepsia. 2019 Mar;60(3):393-405. doi: 10.1111/epi.14661. Epub 2019 Feb 11.
We studied age-related dynamics of information sharing among cortical language regions with electrocorticographic high-gamma modulation during picture-naming and story-listening tasks.
Seventeen epilepsy patients aged 4-19 years, undergoing extraoperative monitoring with left-hemispheric subdural electrodes, were included. Mutual information (MI), a nondirectional measure of shared information, between 16 pairs of cortical regions of interest, was computed from trial-averaged 70-150 Hz power modulations during language tasks. Impact of age on pairwise MI between language regions and their determinants were ascertained with regression analysis.
During picture naming, significant increase in MI with age was seen between pairwise combinations of Broca's area, inferior precentral gyrus (iPreC), and frontal association cortex (FAC); Wernicke's area and posterior association cortex (PAC); and Broca's and Wernicke's areas. During story listening, significant age-related increase in MI was seen between Wernicke's area and either Broca's area, FAC, or PAC; and between Broca's area and FAC. Significant impact of baseline intelligence quotient was seen on the relationship between age and MI for all pairs, except between Broca's area and iPreC. The mean MI was higher during naming compared to listening for pairs including iPreC with Broca's area, FAC, or PAC and was lower for pairs of Wernicke's area or PAC with anterior language regions.
Information sharing matures with age "within" frontal and temporoparietal language cortices, and "between" Broca's and Wernicke's areas. This study provides evidence for distinct patterns of developmental plasticity within perisylvian language cortex and has implications for planning epilepsy surgery.
我们研究了在图片命名和故事倾听任务中，皮质语言区域的电皮质高γ调制与年龄相关的信息共享动态。
纳入了 17 名年龄在 4-19 岁之间、接受左侧半球硬膜下电极进行手术监测的癫痫患者。从语言任务期间平均 70-150 Hz 功率调制的试验中计算了 16 对皮质感兴趣区之间的互信息（MI），这是一种非定向的共享信息测量方法。使用回归分析确定了年龄对语言区域之间的成对 MI 及其决定因素的影响。
在图片命名过程中，Broca 区、下前中央回（iPreC）和额侧联络皮质（FAC）；Wernicke 区和后联络皮质（PAC）之间的成对组合以及 Broca 区和 Wernicke 区之间的 MI 随年龄显著增加。在故事倾听过程中，Wernicke 区与 Broca 区、FAC 或 PAC 之间以及 Broca 区与 FAC 之间的 MI 随年龄显著增加。基线智商的显著影响见于所有配对关系，除了 Broca 区和 iPreC 之间的配对关系。在包括 iPreC 与 Broca 区、FAC 或 PAC 以及 Wernicke 区或 PAC 与前语言区域的配对中，命名的平均 MI 高于倾听，而 Wernicke 区或 PAC 与前语言区域的配对则较低。
信息共享随着年龄在额顶叶语言皮质内“之间”以及 Broca 和 Wernicke 区“之间”成熟。这项研究为在围语皮质内的发育可塑性提供了证据，并对规划癫痫手术具有意义。
