a Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies , Shiraz University of Medical Sciences , Shiraz , Iran.
b Pharmaceutical Sciences Research Center , Shiraz University of Medical Sciences , Shiraz , Iran.
Drug Metab Rev. 2019 Feb;51(1):12-41. doi: 10.1080/03602532.2018.1522328. Epub 2019 Feb 11.
In this Review article, recent progress in matter of graphene oxide (GO) synthesis and its functionalization via a vast range of materials, including small molecules, polymers, and biomolecules, were reported and systematically summarized in order to overcome the inherent drawbacks of GO nanocarriers and thereby make these nanocarriers suitable for delivering chemotherapeutic agents, genes, and short interfering RNAs. Briefly, this work describes current strategies for the large scale production of GO and modification of graphene-based nanocarriers surfaces through practical chemical approaches, improving their biocompatibility and declining their toxicity. It also describes the most relevant cases of study suitable to demonstrate the role of graphene and graphene derivatives (GD) as nanocarrier for anti-cancer drugs and genes (e.g. miRNAs). Moreover, the controlled release mechanisms within the cell compartments and blood pH for targeted therapeutics release in the acidic environment of tumor cells or in intracellular compartments are mentioned and explored.
在这篇综述文章中，报道并系统总结了近年来通过各种材料（包括小分子、聚合物和生物分子）对氧化石墨烯（GO）的合成及其功能化的最新进展，以期克服 GO 纳米载体的固有缺陷，从而使这些纳米载体适合递送达化疗药物、基因和短干扰 RNA。简而言之，这项工作描述了通过实用的化学方法大规模生产 GO 和修饰基于石墨烯的纳米载体表面的当前策略，提高了它们的生物相容性并降低了它们的毒性。它还描述了最相关的研究案例，这些案例证明了石墨烯和石墨烯衍生物（GD）作为抗癌药物和基因（例如 miRNA）的纳米载体的作用。此外，还提到并探讨了细胞区室和血液 pH 值的控制释放机制，以实现针对肿瘤细胞酸性环境或细胞内区室的靶向治疗药物释放。
