Hosseini Seyedeh Neda, Naghib Seyed Morteza, Kashani Ghazal Kadkhodaie, Mozafari M R
Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology, Tehran, P.O. Box 16846-13114, Iran.
Biomaterials and Tissue Engineering Research Group, Interdisciplinary Technologies Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Curr Pharm Des. 2025;31(9):691-715. doi: 10.2174/0113816128333493241014134711.
The effective and prompt treatment of wounds remains a significant challenge in clinical settings. Consequently, recent investigations have led to the development of a novel wound dressing production designed to expedite the process of wound healing with minimal adverse complications. Chitosan, identified as a natural biopolymer, emerges as an appealing option for fabricating environmentally friendly dressings due to its biologically degradable, nonpoisonous, and inherent antimicrobial properties. Concurrently, graphene oxide has garnered attention from researchers as an economical, biocompatible material with non-toxic attributes for applications in wound healing. Chitosan (CS) has been extensively studied in agglutination owing to its advantageous properties, such as Non-toxicity biological compatibility, degradability, and facilitation of collagen precipitation. Nonetheless, its limited Medium mechanical and antibacterial strength characteristics impede its widespread clinical application. In addressing these shortcomings, numerous researchers have embraced nanotechnology, specifically incorporating metal nanoparticles (MNPs), to enhance the mechanical power and targeted germicide features of chitosan multistructures, yielding hopeful outcomes. Additionally, chitosan is a decreasing factor for MNPs, contributing to reduced cytotoxicity. Consequently, the combination of CS with MNPs manifests antibacterial function, superior mechanical power, and anti-inflammatory features, holding significant potential to expedite wound healing. This study delves into based on chitosan graphene materials in the context of wound healing.
在临床环境中，伤口的有效和及时治疗仍然是一项重大挑战。因此，最近的研究促成了一种新型伤口敷料产品的开发，旨在以最小的不良并发症加速伤口愈合过程。壳聚糖作为一种天然生物聚合物，因其具有生物可降解、无毒和固有的抗菌特性，成为制造环保敷料的一个有吸引力的选择。同时，氧化石墨烯作为一种经济、生物相容且无毒的材料，在伤口愈合应用中受到了研究人员的关注。壳聚糖（CS）由于其无毒、生物相容性、可降解性以及促进胶原蛋白沉淀等有利特性，在凝集方面已得到广泛研究。然而，其有限的中等机械强度和抗菌强度特性阻碍了其在临床上的广泛应用。为了解决这些缺点，许多研究人员采用了纳米技术，特别是加入金属纳米颗粒（MNPs），以增强壳聚糖多结构的机械性能和靶向杀菌特性，取得了令人期待的成果。此外，壳聚糖是MNPs的一个减毒因素，有助于降低细胞毒性。因此，CS与MNPs的结合表现出抗菌功能、卓越的机械性能和抗炎特性，在加速伤口愈合方面具有巨大潜力。本研究深入探讨基于壳聚糖石墨烯材料在伤口愈合方面的情况。
