Neuropsychology and Neuroscience Laboratory, Kessler Foundation, West Orange, NJ, USA; Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ, USA; Neuropsychology and Neuroscience Laboratory, Kessler Foundation, East Hanover, NJ, USA.
Neuropsychology and Neuroscience Laboratory, Kessler Foundation, West Orange, NJ, USA.
Mult Scler. 2020 Mar;26(3):354-362. doi: 10.1177/1352458519826463. Epub 2019 Feb 11.
Impairments in new learning and memory are common in individuals with multiple sclerosis (MS), negatively impacting everyday life, including occupational and social functioning.
This study examined the efficacy of the modified Story Memory Technique (mSMT) in a progressive multiple sclerosis (PMS) sample through a double-blind, placebo-controlled, randomized clinical trial (RCT).
Thirty (30) individuals with PMS, naïve to the mSMT, were randomized to the treatment or placebo control group. completed mSMT training twice per week for 5 weeks while the met with the therapist at the same frequency, engaging in non-training-oriented tasks to control for professional contact and disease alterations.
The treatment group showed significant improvements in learning compared with the placebo control group, evident on both objective evaluation of new learning and self-report of functioning in daily life. Increased awareness of cognitive deficits was also noted post-treatment.
These data provide Class I evidence supporting the efficacy of the mSMT in PMS. A behavioral intervention, targeted to specifically strengthen new learning, can significantly improve memory performance in PMS, and this improvement in memory performance is maintained 3 months later.
新学习和记忆损伤在多发性硬化症（MS）患者中很常见，对日常生活产生负面影响，包括职业和社交功能。
本研究通过一项双盲、安慰剂对照、随机临床试验（RCT），检查改良故事记忆技术（mSMT）在进展性多发性硬化症（PMS）患者中的疗效。
30 名 PMS 患者（对 mSMT 不了解）随机分为治疗组或安慰剂对照组。治疗组每周接受 2 次 mSMT 训练，共 5 周，而对照组则在相同频率与治疗师会面，进行非训练导向的任务，以控制专业接触和疾病变化。
与安慰剂对照组相比，治疗组在新学习方面表现出显著改善，客观评估新学习和日常生活功能的自我报告均显示出这种改善。治疗后还注意到认知缺陷的意识增加。
这些数据提供了 I 级证据，支持 mSMT 在 PMS 中的疗效。针对新学习的行为干预可以显著改善 PMS 患者的记忆表现，并且这种记忆表现的改善在 3 个月后仍能维持。
