National Multiple Sclerosis Society, New York, NY, USA.
Division of Child Neurology, Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mult Scler. 2024 Sep;30(10):1242-1251. doi: 10.1177/13524585241266483. Epub 2024 Aug 30.
Multiple sclerosis is a chronic immune-mediated disease of the central nervous system affecting nearly 3 million people worldwide. Although much progress has been made in the understanding and treatment of MS, cures remain elusive.
To accelerate the development of cures for MS by updating the Pathways to Cures Research Roadmap based on a contemporary understanding of disease. The refined Roadmap will help to promote research in scientific areas with great potential to reveal insights leading to cures and inspire greater coordination of global resources.
Refinements to the Roadmap were achieved during a Global Summit that included close to 200 academic and industry scientists, health care providers, policy makers, funders, and people with MS from 15 countries.
The refined Roadmap describes three pathways that target opportunities for generating scientific insights leading to cures. Recommendations for accelerating research progress include, lowering barriers for global data sharing, enhancing collaboration and coordination among research supporters, committing to sustained funding, considering implications for implementation, engaging PwMS and committing to diversity, equity, and inclusion in the global MS movement.
The refined roadmap provides a strategic framework for tackling the complexities of MS and advancing prevention strategies, effective treatments, and cures.
多发性硬化症是一种影响全球近 3000 万人的中枢神经系统慢性免疫介导疾病。尽管人们对多发性硬化症的认识和治疗已经取得了很大的进展，但治愈方法仍难以捉摸。
通过更新基于对疾病的当代理解的“治愈途径研究路线图”，加速多发性硬化症的治愈方法的开发。经过精炼的路线图将有助于促进具有巨大潜力的科学领域的研究，这些研究有可能揭示导致治愈的见解，并激发全球资源更大程度的协调。
在一次全球峰会上对路线图进行了改进，该峰会有来自 15 个国家的近 200 名学术和行业科学家、医疗保健提供者、政策制定者、资助者以及多发性硬化症患者参加。
精炼后的路线图描述了三条针对产生导致治愈的科学见解的机会的途径。加速研究进展的建议包括降低全球数据共享的障碍，加强研究支持者之间的合作与协调，承诺持续提供资金，考虑实施的影响，让患者参与并承诺在全球多发性硬化症运动中实现多样性、公平性和包容性。
经过精炼的路线图为应对多发性硬化症的复杂性以及推进预防策略、有效治疗方法和治愈方法提供了一个战略框架。
