Grozdova M D, Panasiuk A F, Sharlova I L
Biull Eksp Biol Med. 1978 Mar;85(3):287-9.
Radioactive calcium (45Ca) uptake and the effect of adrenaline on this process was studied on the suspension of cells derived from the monolayer cultures of fibroblasts of the skin of healthy donors and of patients with systemic scleroderma and rheumatic fever. A significant increase of calcium uptake was shown in case of scleroderma in comparison with the normal and rheumatism cases. Adrenaline (2 X 10(-7)--2 X 10(-5) M) enhanced the rate of calcium uptake by fibroblasts in control and had the opposite effect in scleroderma. The data obtained indicated alteration of the fibroblast membrane function in systemic scleroderma which could underlay the change in the metabolic activity of these cells.
在来自健康供体、系统性硬皮病患者和风湿热患者皮肤成纤维细胞单层培养物的细胞悬液上，研究了放射性钙（45Ca）摄取以及肾上腺素对该过程的影响。与正常和风湿病例相比，硬皮病病例显示钙摄取显著增加。肾上腺素（2×10（-7）-2×10（-5）M）在对照中提高了成纤维细胞的钙摄取速率，而在硬皮病中则产生相反的效果。所获得的数据表明系统性硬皮病中成纤维细胞膜功能发生改变，这可能是这些细胞代谢活性变化的基础。
