Ibn-Sina Multidisciplinary laboratory, Department of Physics, Shahid Beheshti University, Tehran, P.O.Box: 1983969411, Iran.
Department of Physics, Shahid Beheshti University, Tehran, P.O.Box: 1983969411, Iran.
Sci Rep. 2019 Feb 11;9(1):1751. doi: 10.1038/s41598-018-38215-w.
The speech auditory brainstem response (sABR) is an objective clinical tool to diagnose particular impairments along the auditory brainstem pathways. We explore the scaling behavior of the brainstem in response to synthetic /da/ stimuli using a proposed pipeline including Multifractal Detrended Moving Average Analysis (MFDMA) modified by Singular Value Decomposition. The scaling exponent confirms that all normal sABR are classified into the non-stationary process. The average Hurst exponent is H = 0:77 ± 0:12 at 68% confidence interval indicating long-range correlation which shows the first universality behavior of sABR. Our findings exhibit that fluctuations in the sABR series are dictated by a mechanism associated with long-term memory of the dynamic of the auditory system in the brainstem level. The q-dependency of h(q) demonstrates that underlying data sets have multifractal nature revealing the second universality behavior of the normal sABR samples. Comparing Hurst exponent of original sABR with the results of the corresponding shuffled and surrogate series, we conclude that its multifractality is almost due to the long-range temporal correlations which are devoted to the third universality. Finally, the presence of long-range correlation which is related to the slow timescales in the subcortical level and integration of information in the brainstem network is confirmed.
言语听性脑干反应（sABR）是一种客观的临床工具，可用于诊断听觉脑干通路中的特定损伤。我们使用包括奇异值分解（Singular Value Decomposition）修改的多重分形去趋势移动平均分析（Multifractal Detrended Moving Average Analysis，MFDMA），探索了大脑对合成 /da/ 刺激的脑干缩放行为。缩放指数证实，所有正常的 sABR 都被归类为非平稳过程。平均赫斯特指数 H = 0.77 ± 0.12，置信区间为 68%，表明存在长程相关性，这表现出 sABR 的第一个普适行为。我们的研究结果表明，sABR 序列中的波动是由与大脑脑干水平听觉系统动态的长期记忆相关的机制决定的。q 依赖性 h(q)表明，基础数据集具有多重分形性质，揭示了正常 sABR 样本的第二个普适行为。通过比较原始 sABR 的赫斯特指数与相应的随机和替代序列的结果，我们得出结论，其多重分形性几乎归因于长程时间相关性，这与第三个普适性有关。最后，确认了长程相关性的存在，这种相关性与皮质下水平的慢时间尺度和脑干网络中的信息整合有关。
