Hughes G R
Lupus Research Laboratory, St Thomas' Hospital, London, UK.
Postgrad Med J. 1988 Jul;64(753):517-21. doi: 10.1136/pgmj.64.753.517.
Systemic lupus erythematosus is a common disease--studies throughout the world broadly agree on a prevalence of 1 in 1000 women. Recently an important clinical advance has come from the description of a syndrome of recurrent thrombosis, recurrent abortion and neurological disease associated with antiphospholipid antibodies. The discovery that immunological mechanisms may apply in some cases of thrombosis has led to new insights into the aetiology and treatment of vascular disease in general.
系统性红斑狼疮是一种常见疾病——世界各地的研究普遍认为,每1000名女性中就有1人患病。最近,一项重要的临床进展来自于对一种与抗磷脂抗体相关的复发性血栓形成、复发性流产和神经疾病综合征的描述。免疫机制可能在某些血栓形成病例中起作用这一发现,总体上为血管疾病的病因学和治疗带来了新的见解。