Department of Dermatology, Third Xiangya Hospital of Central South University, Changsha, Hunan 41006, China.
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Int Immunopharmacol. 2019 Apr;69:263-269. doi: 10.1016/j.intimp.2019.01.030. Epub 2019 Feb 8.
Atopic dermatitis (AD) is a chronic, non-contagious, inflammatory skin disorder characterized by relapsing eczematous lesions. Its pathogenesis remains incompletely understood. The current evidence has emerged to show that skin and gut microbiome play critical roles in the pathogenesis and progression of AD. Skin mircrobiome mainly refers to skin commensal organisms that promote normal immune system functions and prevent the colonization of pathogens; while gut microbiome can modulate immunologic, metabolic and neuroendocrine functions. With the current knowledge of microbiome effects on the onset of the disease, there are evolving multifarious interventions targeting microbiome for the treatment of AD. In this report, we have reviewed the critical roles of microbiosis in the pathogenesis of AD, summarized potential mechanisms mediated by microbiosis and aimed to enlighten a theoretical basis for its therapeutic applications in the treatment of AD.
特应性皮炎（AD）是一种慢性、非传染性、炎症性皮肤病，其特征为反复发作的湿疹样病变。其发病机制尚不完全清楚。目前的证据表明，皮肤和肠道微生物组在 AD 的发病机制和进展中起着关键作用。皮肤微生物组主要是指促进正常免疫系统功能和防止病原体定植的皮肤共生生物体；而肠道微生物组可以调节免疫、代谢和神经内分泌功能。随着对微生物组对疾病发生影响的了解，目前有许多针对微生物组的干预措施正在被开发出来，用于治疗 AD。在本报告中，我们回顾了微生物组在 AD 发病机制中的关键作用，总结了微生物组介导的潜在机制，并旨在为其在 AD 治疗中的治疗应用提供理论基础。
