Department of Dermatology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou 318000, China.
Department of Dermatology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou 318000, China.
Int Immunopharmacol. 2024 Nov 15;141:112658. doi: 10.1016/j.intimp.2024.112658. Epub 2024 Aug 12.
Atopic dermatitis (AD) and psoriasis are chronic skin diseases with a global impact, posing significant challenges to public health systems and severely affecting patients' quality of life. This review delves into the key role of the gut microbiota in these diseases, emphasizing the importance of the gut-skin axis in inflammatory mediators and immune regulation and revealing a complex bidirectional communication system. We comprehensively assessed the pathogenesis, clinical manifestations, and treatment strategies for AD and psoriasis, with a particular focus on how the gut microbiota and their metabolites influence disease progression via the gut-skin axis. In addition, personalized treatment plans based on individual patient microbiome characteristics have been proposed, offering new perspectives for future treatment approaches. We call for enhanced interdisciplinary cooperation to further explore the interactions between gut microbiota and skin diseases and to assess the potential of drugs and natural products in modulating the gut-skin axis, aiming to advance the treatment of skin diseases.
特应性皮炎（AD）和银屑病是具有全球影响的慢性皮肤病，对公共卫生系统构成重大挑战，严重影响患者的生活质量。本综述深入探讨了肠道微生物群在这些疾病中的关键作用，强调了肠-皮肤轴在炎症介质和免疫调节中的重要性，并揭示了一个复杂的双向通讯系统。我们全面评估了 AD 和银屑病的发病机制、临床表现和治疗策略，特别关注肠道微生物群及其代谢物如何通过肠-皮肤轴影响疾病进展。此外，还根据个体患者的微生物组特征提出了个性化的治疗方案，为未来的治疗方法提供了新的视角。我们呼吁加强跨学科合作，进一步探索肠道微生物群与皮肤疾病之间的相互作用，并评估药物和天然产物调节肠-皮肤轴的潜力，旨在推进皮肤疾病的治疗。
