Programa de Doctorado, Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.
Int J Mol Sci. 2019 Feb 9;20(3):735. doi: 10.3390/ijms20030735.
Acute leukemia (AL) is the main type of cancer in children worldwide. Mortality by this disease is high in developing countries and its etiology remains unanswered. Evidences showing the role of the long non-coding RNAs (lncRNAs) in the pathophysiology of hematological malignancies have increased drastically in the last decade. In addition to the contribution of these lncRNAs in leukemogenesis, recent studies have suggested that lncRNAs could be used as biomarkers in the diagnosis, prognosis, and therapeutic response in leukemia patients. The focus of this review is to describe the functional classification, biogenesis, and the role of lncRNAs in leukemogenesis, to summarize the evidence about the lncRNAs which are playing a role in AL, and how these genes could be useful as potential therapeutic targets.
急性白血病（AL）是全球儿童中主要的癌症类型。在发展中国家，这种疾病的死亡率很高，其病因仍未得到解答。在过去十年中，大量证据表明长链非编码 RNA（lncRNA）在血液恶性肿瘤的病理生理学中起作用。除了这些 lncRNA 在白血病发生中的作用外，最近的研究还表明，lncRNA 可以作为白血病患者诊断、预后和治疗反应的生物标志物。本综述的重点是描述 lncRNA 的功能分类、生物发生以及在白血病发生中的作用，总结在 AL 中起作用的 lncRNA 的证据，以及这些基因如何作为潜在的治疗靶点有用。
