新型寡聚混合配体配合物的设计：制备、生物应用及首例纳米级实例。

Design of Novel Oligomeric Mixed Ligand Complexes: Preparation, Biological Applications and the First Example of Their Nanosized Scale.

机构信息

Department of Chemistry, Taibah University, 30002 Al-Madinah Al-Munawarah, Saudi Arabia.

Chemistry Department, Faculty of Science, Ain Shams University, 11566 Cairo, Egypt.

出版信息

Int J Mol Sci. 2019 Feb 10;20(3):743. doi: 10.3390/ijms20030743.

A successful oligomerization of ternary metal complexes, cobalt (II), nickel (II), copper (II), zinc (II), chromium (III) and ferric sulfate (III) with nitrilotriacetic acid (NTA) as a primary ligand and glutamic acid as a secondary ligand, has been demonstrated. The formation of oligomers arose from the presence of the sulfate moiety, which operates as a bridged bidentate ligand that coordinates with other metal moieties. The novel oligomers exhibited octahedral structures, which bonded together through the sulfate moiety. In silico predictions were conducted to gauge the bioactivity, physico-chemical and pharmacokinetic properties. The biological activities of these oligomers as well as their tumor inhibitory behavior have been explored. This work also presents a facile and novel method of preparing these materials in nanosize, using Cetyltrimethylammonium bromide (CTAB) and polyvinyl alcohol (PVA) as capping ligands. The size and shape of the nanomaterials have been confirmed using the transmission electron microscope (TEM) and the scanning electron microscope (SEM).

成功地将三元金属配合物（钴(II)、镍(II)、铜(II)、锌(II)、铬(III)和硫酸铁(III)）与次氮基三乙酸（NTA）作为主要配体和谷氨酸作为次要配体进行了三聚。三聚体的形成源于硫酸盐部分的存在，它作为桥联双齿配体与其他金属部分配位。新型寡聚物呈现八面体结构，通过硫酸盐部分键合在一起。进行了计算机预测以评估生物活性、物理化学和药代动力学性质。研究了这些寡聚物的生物活性及其肿瘤抑制行为。本工作还提出了一种简便而新颖的方法，使用十六烷基三甲基溴化铵（CTAB）和聚乙烯醇（PVA）作为封端配体，在纳米尺寸下制备这些材料。使用透射电子显微镜（TEM）和扫描电子显微镜（SEM）确认了纳米材料的尺寸和形状。