Izer Jenelle, Mattern Erin, Ellwanger Joy, Wilson Ronald
Department of Comparative Medicine, Penn State Milton S Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Department of Comparative Medicine, Penn State Milton S Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.
Vet Anaesth Analg. 2019 Mar;46(2):209-213. doi: 10.1016/j.vaa.2018.12.003. Epub 2019 Jan 21.
To determine the degree of agreement between arterial and venous blood gases in anesthetized lambs using a point-of-care analyzer.
Prospective experimental study.
A group of 12 female Dorset cross-bred lambs, weighing 37.3 ± 7.4 kg (mean ± standard deviation).
Lambs were anesthetized with isoflurane for catheterization of the jugular vein and femoral artery, and blood samples were collected simultaneously for analysis of pH, PCO, PO, base excess (BE), bicarbonate ( [Formula: see text] ), total carbon dioxide (tCO), oxygen saturation (SO), ionized calcium (iCa) and potassium (K) using the Vet Scan i-STAT handheld analyzer. The Bland-Altman method was used to calculate agreement between arterial and venous measurements.
Strong agreement was identified between arterial and venous pH (bias = 0.04; 95% limits of agreement = 0.02-0.06), K (bias = -0.1 and 95% limits of agreement = -0.8 to 0.5) and iCa (bias = 0.04; 95% limits of agreement = -0.08 to 0.0003). There was poor agreement for PO (bias = 168.0; 95% limits of agreement = 77.4-258.7) and SO (bias = 9.1; 95% limits of agreement = 2.8-15.3), as these values were higher in arterial blood than in venous blood. Moderate agreement was present for BE (bias = 1.7; 95% limits of agreement = -2.7 to 6.1), PCO (bias = -2.1; 95% limits of agreement = -7.5 to 3.4), [Formula: see text] (bias = 1.1; 95% limits of agreement = -3.1 to 5.3) and tCO (bias = 1.0; 95% limits of agreement = -3.3 to 5.3).
Venous blood can be used for the measurement of pH, K and iCa in anesthetized Dorset cross-bred lambs. Arterial blood is required for accurate measurement of PO, SO, PCO, [Formula: see text] , tCO and BE to assess systemic blood oxygenation and pulmonary function in anesthetized Dorset cross-bred lambs.
使用即时检验分析仪确定麻醉羔羊动脉血气与静脉血气之间的一致程度。
前瞻性实验研究。
一组12只雌性多塞特杂交羔羊，体重37.3±7.4千克（均值±标准差）。
用异氟烷麻醉羔羊以进行颈静脉和股动脉插管，并同时采集血样，使用Vet Scan i-STAT手持式分析仪分析pH、PCO₂、PO₂、碱剩余（BE）、碳酸氢盐（[公式：见原文]）、总二氧化碳（tCO₂）、氧饱和度（SO₂）、离子钙（iCa）和钾（K）。采用布兰德-奥特曼方法计算动脉和静脉测量值之间的一致性。
动脉和静脉pH（偏差=0.04；95%一致性界限=0.02 - 0.06）、K（偏差=-0.1且95%一致性界限=-0.8至0.5）和iCa（偏差=0.04；95%一致性界限=-0.08至0.0003）之间存在高度一致性。PO₂（偏差=168.0；95%一致性界限=77.4 - 258.7）和SO₂（偏差=9.1；95%一致性界限=2.8 - 15.3）的一致性较差，因为这些值在动脉血中高于静脉血。BE（偏差=1.7；95%一致性界限=-2.7至6.1）、PCO₂（偏差=-2.1；95%一致性界限=-7.5至3.4）、[公式：见原文]（偏差=1.1；95%一致性界限=-3.1至5.3）和tCO₂（偏差=1.0；95%一致性界限=-3.3至5.3）存在中等程度的一致性。
静脉血可用于测量麻醉的多塞特杂交羔羊的pH、K和iCa。准确测量PO₂、SO₂、PCO₂、[公式：见原文]、tCO₂和BE以评估麻醉的多塞特杂交羔羊的全身血液氧合和肺功能需要动脉血。
