Duzce University, Faculty of Health Sciences, Department of Nursing, Duzce, Turkey.
Duzce University, Faculty of Medicine, Department of Biostatistics and Medical Informatics, Duzce, Turkey.
J Pediatr Nurs. 2019 Mar-Apr;45:e95-e101. doi: 10.1016/j.pedn.2019.02.001. Epub 2019 Feb 8.
This study was performed to determine the effect of oral care using chlorhexidine, vitamin E and honey on oral mucositis (OM) management in children treated in a pediatric intensive care unit (PICU).
The study was a randomized controlled trial with a parallel design. The study sample was composed of 150 children who were treated in the PICU of a university hospital in Turkey. Children enrolled in the study were randomly divided into six groups based on the oral care solutions used (n = 25 in each group). The Demographic Information Form and the World Health Organization Oral Mucositis Index were used for data collection.
The mucositis indices of the children presenting with and without OM upon admission to the PICU were compared on days 1, 3, 6, 9, 12, 15, 18 and 21 and the study found that the mucositis index values of the children treated with vitamin E were significantly lower than in the other groups (p < 0.05 for each), while those of the children given chlorhexidine were significantly higher than in the other groups (p < 0.05 for each).
At the end of the study, vitamin E was determined to be the most effective agent in OM management, followed by honey as the second most effective agent. Chlorhexidine was found to be less effective in OM management compared to the other two agents. Based on this, vitamin E is recommended for use in oral mucositis-preventive and therapeutic oral care practices.
The results of the present study conducted with PICU patients will be useful in the administration of oral care. These findings are also important for nurses who have the responsibility of oral mucositis management.
本研究旨在确定在儿科重症监护病房（PICU）接受治疗的儿童中，使用洗必泰、维生素 E 和蜂蜜进行口腔护理对口腔黏膜炎（OM）管理的影响。
这是一项随机对照试验，采用平行设计。研究样本由在土耳其一所大学医院 PICU 接受治疗的 150 名儿童组成。根据使用的口腔护理溶液，将入组儿童随机分为六组（每组 25 名）。使用人口统计学信息表和世界卫生组织口腔黏膜炎指数收集数据。
比较了 PICU 入院时伴有和不伴有 OM 的儿童在第 1、3、6、9、12、15、18 和 21 天的口腔黏膜炎指数，研究发现，接受维生素 E 治疗的儿童的口腔黏膜炎指数显著低于其他组（p<0.05 各时间点），而接受洗必泰治疗的儿童的口腔黏膜炎指数显著高于其他组（p<0.05 各时间点）。
研究结束时，确定维生素 E 是 OM 管理中最有效的药物，其次是蜂蜜，是第二有效的药物。与其他两种药物相比，洗必泰在 OM 管理中的效果较差。基于此，建议在口腔黏膜炎预防和治疗性口腔护理实践中使用维生素 E。
本研究对 PICU 患者进行的研究结果将有助于口腔护理的实施。这些发现对于负责口腔黏膜炎管理的护士也很重要。
