Guo Wenzhi, Zhang Jiakai, Zhang Dongyu, Cao Shengli, Li Gongquan, Zhang Shuijun, Wang Zhihui, Wen Peihao, Yang Han, Shi Xiaoyi, Pan Jie, Ye Hua
Department of Hepatic and Biliary Pancreatic Surgery, Henan Key Laboratory of Digestive Organ Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China.
Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, P.R. China.
Oncotarget. 2017 Jul 18;8(29):48169-48177. doi: 10.18632/oncotarget.18327.
Hepatocellular carcinoma (HCC) ranks the sixth most common cancer and the third cause of cancer-related mortality worldwide. Recent studies identified that circ-ITCH Suppresses mutiple cancers proliferation via inhibiting the Wnt/beta-Catenin pathway. In current study, conducted a genetic association study together with epidemiological follow-up study to delineate the role of circ-ITCH in the development and progression of HCC. we found rs10485505 (adjusted OR =1.18; 95% CI=1.06-1.31; P value =3.1×10-3) and rs4911154 (adjusted OR =1.27; 95% CI=1.14-1.43; P value =3.7×10-5) were significantly associated with increased HCC risk. The expression level of circ-ITCH was significantly lower in HCC tissues, compared with that in adjacent tissues (P value < 0.001). Cox regression analysis indicated that high expression of circ-ITCH was associated with favorable survival of HCC (HR=0.45; 95% CI=0.29-0.68; P value < 0.001). These results indicate that circ-ITCH may have an inhibitory effect on HCC, and could serve as susceptibility and prognostic biomarkers for HCC patients.
肝细胞癌（HCC）是全球第六大常见癌症，也是癌症相关死亡的第三大原因。最近的研究发现，环状ITCH通过抑制Wnt/β-连环蛋白信号通路抑制多种癌症的增殖。在本研究中，我们进行了一项基因关联研究以及流行病学随访研究，以阐明环状ITCH在HCC发生发展中的作用。我们发现，rs10485505（校正比值比=1.18；95%置信区间=1.06-1.31；P值=3.1×10-3）和rs4911154（校正比值比=1.27；95%置信区间=1.14-1.43；P值=3.7×10-5）与HCC风险增加显著相关。与癌旁组织相比，环状ITCH在HCC组织中的表达水平显著降低（P值<0.001）。Cox回归分析表明，环状ITCH的高表达与HCC患者的良好生存相关（风险比=0.45；95%置信区间=0.29-0.68；P值<0.001）。这些结果表明，环状ITCH可能对HCC具有抑制作用，并可作为HCC患者的易感性和预后生物标志物。
