营养在非酒精性脂肪性肝病发病机制和预防中的作用：最新进展。
Role of Nutrition in the Pathogenesis and Prevention of Non-alcoholic Fatty Liver Disease: Recent Updates.
机构信息
Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310051, China.
Department of Neurobiology, Institute of Neuroscience, and the Collaborative Innovation Center for Brain Science, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University School of Medicine, Hangzhou 310058, China.
出版信息
Int J Biol Sci. 2019 Jan 1;15(2):265-276. doi: 10.7150/ijbs.30121. eCollection 2019.
Non-alcoholic fatty liver disease (NAFLD) is an acquired metabolic disease characterized by triglycerides (TGs) deposition in liver induced by other factors rather than alcohol consumption. NAFLD significantly contributes to liver diseases in children and adults. NAFLD pathogenesis is associated with age, gender, race and ethnicity. Insulin resistance, hyperinsulinemia, elevated plasma free fatty acids (FFAs), fatty liver, hepatocyte injury, liver inflammation, oxidative stress, mitochondrial dysfunction, imbalanced pro-inflammatory cytokines, and fibrosis are the characteristics of NAFLD. Factors including genetic and epigenetic pathways, sedentary lifestyle, sleep, and diet composition affect NAFLD pathogenesis. In this review, we discuss the aetiology, risk factors and pathogenesis of NAFLD. Special focus is given to macro and micro nutrition as causing factors and their role in the prevention of NAFLD pathogenesis.
非酒精性脂肪性肝病（NAFLD）是一种获得性代谢疾病，其特征为肝脏内甘油三酯（TGs）沉积，由其他因素引起，而非酒精摄入。NAFLD 可导致儿童和成人的肝脏疾病。NAFLD 的发病机制与年龄、性别、种族和民族有关。胰岛素抵抗、高胰岛素血症、血浆游离脂肪酸（FFAs）升高、脂肪肝、肝细胞损伤、肝炎症、氧化应激、线粒体功能障碍、促炎细胞因子失衡和纤维化是 NAFLD 的特征。遗传和表观遗传途径、久坐的生活方式、睡眠和饮食组成等因素影响 NAFLD 的发病机制。在这篇综述中，我们讨论了 NAFLD 的病因、危险因素和发病机制。特别关注宏量和微量营养素作为致病因素及其在预防 NAFLD 发病机制中的作用。
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