Ozlu Tevfik, Bulbul Yilmaz, Aydin Derya, Tatar Dursun, Kuyucu Tulin, Erboy Fatma, Koseoglu Handan Inonu, Anar Ceyda, Sunnetcioglu Aysel, Gulhan Pinar Yildiz, Sahin Unal, Ekici Aydanur, Duru Serap, Ulasli Sevinc Sarinc, Kurtipek Ercan, Gunay Sibel
Department of Chest Diseases, School of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Chest Disease Clinic, Pulmonary Diseases Hospital, Balikesir, Turkey.
Ann Thorac Med. 2019 Jan-Mar;14(1):75-82. doi: 10.4103/atm.ATM_145_18.
The purpose of this study is to detect the prevalence and the factors associated with influenza and pneumococcal vaccination and outcomes of vaccination during 2013-2014 season in patients with chronic obstructive pulmonary disease (COPD) in Turkey.
This was a multicenter retrospective cohort study performed in 53 different centers in Turkey.
During the study period, 4968 patients were included. COPD was staged as GOLD 1-2-3-4 in 9.0%, 42.8%, 35.0%, and 13.2% of the patients, respectively. Influenza vaccination rate in the previous year was 37.9%; and pneumococcus vaccination rate, at least once during in a life time, was 13.3%. Patients with older age, higher level of education, more severe COPD, and comorbidities, ex-smokers, and patients residing in urban areas had higher rates of influenza vaccination. Multivariate logistic regression analysis showed that advanced age, higher education levels, presence of comorbidities, higher COPD stages, and exacerbation rates were associated with both influenza and pneumococcal vaccination. The number of annual physician/outpatient visits and hospitalizations due to COPD exacerbation was 2.73 ± 2.85 and 0.92 ± 1.58 per year, respectively. Patients with older age, lower education levels, more severe COPD, comorbid diseases, and lower body mass index and patients who are male and are residing in rural areas and vaccinated for influenza had significantly higher rates of COPD exacerbation.
The rates of influenza and pneumococcal vaccination in COPD patients were quite low, and the number of annual physician/outpatient visits and hospitalizations due to COPD exacerbation was high in Turkey. Advanced age, higher education levels, comorbidities, and higher COPD stages were associated with both influenza and pneumococcal vaccination.
本研究旨在检测2013 - 2014季节土耳其慢性阻塞性肺疾病（COPD）患者流感和肺炎球菌疫苗接种的流行情况、相关因素及接种结果。
这是一项在土耳其53个不同中心开展的多中心回顾性队列研究。
研究期间，共纳入4968例患者。COPD患者中，GOLD 1 - 2 - 3 - 4期分别占9.0%、42.8%、35.0%和13.2%。上一年度流感疫苗接种率为37.9%；肺炎球菌疫苗接种率（一生中至少接种一次）为13.3%。年龄较大、教育程度较高、COPD病情较重、有合并症、既往吸烟者以及居住在城市地区的患者流感疫苗接种率较高。多因素逻辑回归分析显示，高龄、教育程度较高、存在合并症、COPD分期较高以及急性加重率与流感和肺炎球菌疫苗接种均相关。因COPD急性加重导致的每年医生门诊就诊次数和住院次数分别为2.73±2.85次和0.92±1.58次。年龄较大、教育程度较低、COPD病情较重、有合并疾病、体重指数较低以及男性、居住在农村地区且接种流感疫苗的患者COPD急性加重率显著较高。
土耳其COPD患者的流感和肺炎球菌疫苗接种率相当低，且因COPD急性加重导致的每年医生门诊就诊次数和住院次数较高。高龄、教育程度较高、合并症以及COPD分期较高与流感和肺炎球菌疫苗接种均相关。
