钙拮抗剂作为一种对人体外周起作用的迷路抑制药。

Calcium antagonists as a peripherally acting labyrinthine suppressant in humans.

作者信息

Mangabeira-Albernaz P L

机构信息

Department of Otolaryngology, Escola Paulista de Medicina, São Paulo, Brazil.

出版信息

Acta Otolaryngol Suppl. 1988;460:99-103. doi: 10.3109/00016488809125142.

DOI:10.3109/00016488809125142

PMID:3074621

Abstract

A total of 908 patients with peripheral vestibular disorders were treated with calcium antagonists for periods of 10 to 120 days in a series of controlled clinical trials using a placebo or other medication for comparison. The cumulative analysis of the results indicates that cinnarizine, flunarizine and bencyclan have produced good clinical results, particularly in patients with vascular problems. A comparison between different doses used in different trials revealed a correlation of good clinical results to smaller doses of some of these medications.

摘要

在一系列对照临床试验中，使用安慰剂或其他药物作为对照，共908例外周前庭疾病患者接受了钙拮抗剂治疗，疗程为10至120天。结果的累积分析表明，桂利嗪、氟桂利嗪和苄环烷产生了良好的临床效果，特别是在患有血管问题的患者中。不同试验中使用的不同剂量之间的比较显示，这些药物中某些较小剂量与良好的临床效果相关。