口服法莫替丁的频率会随时间影响其对猫胃内pH值的作用。
The frequency of oral famotidine administration influences its effect on gastric pH in cats over time.
作者信息
Golly Elizabeth, Odunayo Adesola, Daves Maggie, Vose Julie, Price Josh, Hecht Silke, Steiner Joerg M, Hillsman Shanna, Tolbert M Katherine
机构信息
Department of Small Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, Tennessee.
Department of Small Animal Clinical Sciences, Gastrointestinal Laboratory, Texas A&M University, College Station, Texas.
出版信息
J Vet Intern Med. 2019 Mar;33(2):544-550. doi: 10.1111/jvim.15430. Epub 2019 Feb 12.
BACKGROUND
Famotidine is commonly administered to cats. Prolonged famotidine administration results in decreased efficacy in humans, dogs, and cows, but the long-term effects in cats are unknown.
OBJECTIVES
To compare the effect of 2 oral administration frequencies of famotidine, twice daily (Group 1) and twice daily every second day (Group 2), on intragastric pH and serum gastrin concentrations in cats. We hypothesized a diminished effect on intragastric pH would be observed over time in Group 1 but not Group 2.
ANIMALS
Sixteen healthy cats.
METHODS
Randomized, 2-factor repeated measures crossover design. Cats received 0.5-1.24 mg/kg (median, 0.87 mg/kg) famotidine twice daily or twice daily every second day for 14 consecutive days. Intragastric pH monitoring was used to record intragastric pH on treatment days 1-3 and 11-13. Mean pH and mean percentage time (MPT) intragastric pH was ≥3 and 4 were compared between and within treatment groups by analysis of variance.
RESULTS
Significant treatment group by time interactions were observed for mean intragastric pH, MPT intragastric pH ≥3 and 4 (P = .009, P = .02, P = .005, respectively). Interaction post hoc tests identified significant decreases in mean intragastric pH (P = .001), MPT ≥3 (P = .001), and MPT ≥4 (P = .001) on day 13 compared to day 1 in Group 1 but not in Group 2.
CONCLUSIONS AND CLINICAL IMPORTANCE
Oral famotidine administration results in a diminished effect on intragastric pH in healthy cats when given twice daily every day.
背景
法莫替丁常用于猫。在人类、犬类和牛中，长期使用法莫替丁会导致疗效降低，但在猫中的长期影响尚不清楚。
目的
比较法莫替丁两种口服给药频率（每日两次，第1组；每隔一天每日两次，第2组）对猫胃内pH值和血清胃泌素浓度的影响。我们假设随着时间推移，第1组对胃内pH值的影响会减弱，而第2组不会。
动物
16只健康猫。
方法
随机、双因素重复测量交叉设计。猫连续14天每天接受0.5 - 1.24毫克/千克（中位数，0.87毫克/千克）法莫替丁，每日两次或每隔一天每日两次。在治疗第1 - 3天和第11 - 13天，使用胃内pH监测记录胃内pH值。通过方差分析比较治疗组间和组内胃内平均pH值以及胃内pH值≥3和4的平均百分比时间（MPT）。
结果
在胃内平均pH值、MPT胃内pH值≥3和4方面观察到显著的治疗组×时间交互作用（分别为P = 0.009、P = 0.02、P = 0.005）。交互作用的事后检验表明，与第1天相比，第13天第1组的胃内平均pH值（P = 0.001）、MPT≥3（P = 0.001）和MPT≥4（P = 0.001）显著降低，而第2组未出现这种情况。
结论及临床意义
健康猫每天口服法莫替丁会导致对胃内pH值的影响减弱。
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