Ryan Phillip, Odunayo Adesola, Price Josh, Hecht Silke, Hillsman Shanna, Galyon Gina, Steiner Joerg, Tolbert M Katherine
Department of Small Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee, USA.
Department of Small Animal Clinical Sciences, Texas A&M University, College of Veterinary Medicine and Biomedical Sciences, College Station, Texas, USA.
J Vet Intern Med. 2020 Sep;34(5):1879-1885. doi: 10.1111/jvim.15887. Epub 2020 Sep 4.
Proton pump inhibitors (PPIs) are among the most commonly prescribed medications for esophagitis and upper gastrointestinal erosion and ulceration in cats. Newer PPIs such as lansoprazole and esomeprazole are believed to be effective in cats, but the effect of many of these PPIs on gastric pH in cats has not been explored.
HYPOTHESIS/OBJECTIVES: To evaluate the efficacy of PO esomeprazole, dexlansoprazole, and lansoprazole on intragastric pH in healthy cats. We hypothesized that esomeprazole and lansoprazole would provide superior acid suppression compared to dexlansoprazole and reach pH goals extrapolated from people for the treatment of esophagitis and duodenal ulceration.
Twelve healthy research cats.
Randomized, 3-way crossover study. Cats were given esomeprazole and lansoprazole at a dosage of 1 mg/kg PO q12h or dexlansoprazole at 6 mg/kg PO q12h. Intragastric pH was recorded at baseline and for 4 days of treatment. Mean pH and the mean percentage time (MPT) intragastric pH was ≥3 or ≥4 were compared among and within treatment groups.
Cats treated with lansoprazole had a lower MPT ± SD of intragastric pH ≥3 (8.8 ± 6.8%) and mean ± SD pH (1.6 ± 0.5) than did cats treated with dexlansoprazole (41.2 ± 34.6% and 3.11 ± 1.6, respectively) or esomeprazole (54 ± 33.8% and 4.1 ± 3.9, respectively;P ≤ .04). Esomeprazole was the only treatment that achieved the goals defined for people for the treatment of duodenal ulceration by Day 4 of treatment (MPT ± SD of intragastric pH ≥4 of 77.1 ± 29.2%).
Orally administered esomeprazole might be a superior acid suppressant in cats compared to PO lansoprazole or dexlansoprazole.
质子泵抑制剂（PPIs）是猫食管炎及上消化道糜烂和溃疡最常用的处方药。人们认为兰索拉唑和埃索美拉唑等新型PPIs对猫有效，但其中许多PPIs对猫胃内pH值的影响尚未得到研究。
假设/目的：评估口服埃索美拉唑、右兰索拉唑和兰索拉唑对健康猫胃内pH值的疗效。我们假设，与右兰索拉唑相比，埃索美拉唑和兰索拉唑能提供更好的抑酸效果，并达到从人类治疗食管炎和十二指肠溃疡推断出的pH值目标。
12只健康的研究用猫。
随机、三向交叉研究。给猫分别口服剂量为1mg/kg、每12小时一次的埃索美拉唑和兰索拉唑，或口服剂量为6mg/kg、每12小时一次的右兰索拉唑。在基线及治疗4天期间记录胃内pH值。比较各治疗组之间及组内胃内pH值≥3或≥4时的平均pH值和平均时间百分比（MPT）。
与接受右兰索拉唑治疗的猫（分别为41.2±34.6%和3.11±1.6）或埃索美拉唑治疗的猫（分别为54±33.8%和 4.1±3.9）相比，接受兰索拉唑治疗的猫胃内pH值≥3时的MPT±标准差（8.8±6.8%）和平均±标准差pH值（1.6±0.5）更低（P≤0.04）。埃索美拉唑是唯一在治疗第4天达到人类治疗十二指肠溃疡所定义目标的治疗方法（胃内pH值≥4时的MPT±标准差为77.1±29.2%）。
与口服兰索拉唑或右兰索拉唑相比，口服埃索美拉唑对猫可能是一种更好的抑酸剂。
