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评估一种结构化个体化方案作为犬慢性腹泻潜在的具有成本效益的诊断和治疗方法。

Evaluation of a structured individualised protocol as a potential cost-effective diagnostic and therapeutic approach to chronic diarrhoea in the dog.

作者信息

Bryan Christine E, Cade Jeb C, Mackin Andrew J, Sullivant Alyssa M

机构信息

Department of Clinical Sciences, Mississippi State University College of Veterinary Medicine, Mississippi State, Mississippi, USA.

出版信息

Vet Med Sci. 2019 May;5(2):210-221. doi: 10.1002/vms3.154. Epub 2019 Feb 11.

Abstract

Diagnostic investigation and management of chronic diarrhoea in dogs can be cost-prohibitive to many owners. The objectives of this study were to evaluate evidence-based, individualised diagnostic and therapeutic protocols for management of dogs with chronic diarrhoea, where financial constraints dictate a budget-limited approach and where more expensive approaches are deferred until simple affordable protocols are unsuccessful. Twenty-two client-owned dogs with chronic (minimum 2 weeks duration) untreated small, large or mixed small/large bowel diarrhoea were enrolled in a budget-limited step-wise management protocol (maximum expenditure $300 over 6 weeks), with diagnostic testing and therapeutic trials managed in an individualised and evidence-based fashion. Success was defined as complete resolution of diarrhoea for a minimum of 1 month. Dogs that failed to respond to a budget-limited protocol were then enrolled for complete, referral-level management. Four dogs exited the project early (one death due to caval syndrome, three lost to follow-up). Thirteen out of the remaining 18 dogs had complete resolution of diarrhoea utilising a budget-limited approach (success rate 72.2%, confidence intervals 46.5-90.3%) and five dogs were moved on to a referral-level investigation, with complete resolution of diarrhoea in four out of five. Seventeen out of the 18 dogs therefore responded to a protocol based on a budget-limited approach followed by extensive investigation only if needed, for an overall success rate of 94.4% (CI 72.7-99.9%). Comprehensive investigation of chronic diarrhoea can be deferred while simple affordable diagnostics and therapeutic trials are conducted in stable canine patients and, often, an extensive management approach will be unnecessary.

摘要

对许多犬主来说,犬慢性腹泻的诊断性检查和治疗费用可能过高。本研究的目的是评估针对患有慢性腹泻犬只的循证个体化诊断和治疗方案,在经济限制决定采取预算有限方法且在简单实惠方案未成功之前推迟采用更昂贵方法的情况下。22只客户拥有的患有慢性(持续时间至少2周)未治疗的小肠、大肠或混合性小肠/大肠腹泻的犬只被纳入预算有限的逐步管理方案(6周内最大支出300美元),诊断测试和治疗试验以个体化和循证方式进行管理。成功定义为腹泻完全缓解至少1个月。对预算有限方案无反应的犬只随后被纳入全面的转诊级管理。4只犬提前退出项目(1只因腔静脉综合征死亡,3只失访)。其余18只犬中有13只采用预算有限方法使腹泻完全缓解(成功率72.2%,置信区间46.5 - 90.3%),5只犬进入转诊级检查,其中4只腹泻完全缓解。因此,18只犬中有17只对基于预算有限方法的方案有反应,仅在需要时进行广泛检查,总体成功率为94.4%(CI 72.7 - 99.9%)。在对稳定的犬类患者进行简单实惠的诊断和治疗试验时,可以推迟对慢性腹泻的全面检查,而且通常无需采用广泛的管理方法。

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