探究烧结温度对生物医学应用的天然羟基磷灰石的影响。
Exploring the effect of sintering temperature on naturally derived hydroxyapatite for bio-medical applications.
机构信息
Department of Ceramic Technology, Alagapa College of Technology, Anna University, Chennai, TN, 600 025, India.
Biomaterials Department, CSIR-Central Leather Research Institute, Adyar, Chennai, TN, 600 020, India.
出版信息
J Mater Sci Mater Med. 2019 Feb 12;30(2):21. doi: 10.1007/s10856-019-6219-9.
The current work describes the influence of sintering temperatures on biological and mechanical properties of naturally derived hydroxyapatite (HAp). The phase pure hydroxyapatite developed from the goat bone has been obtained by optimizing the calcination temperature from 600-900 °C. Further, HAp calcined at 900 °C was subjected to various sintering temperature (1100-1400 °C). Finally, the influence of sinter temperatures on mechanical (hardness) and biological properties (in vitro bioactivity, MTT and hemocompatibility assays) were ascertained. In respect of biological properties, it came to know that 1300 °C is optimum sinter temperature, which has enhanced apatite growth with the superior cell viability and hemo-compatible behavior. However, sample sintered at 1400 °C delivers maximum hardness. Thus, the hydroxyapatite extracted from goat bone can find better applications in bio-medical engineering as analogous to the existing man-made synthetic materials.
本工作描述了烧结温度对天然来源的羟基磷灰石（HAp）的生物和力学性能的影响。通过优化从 600-900°C 的煅烧温度，从山羊骨中开发出了具有纯相的羟基磷灰石。此外，将在 900°C 下煅烧的 HAp 进行各种烧结温度（1100-1400°C）处理。最后，确定了烧结温度对机械性能（硬度）和生物性能（体外生物活性、MTT 和血液相容性测定）的影响。就生物性能而言，发现 1300°C 是最佳的烧结温度，它促进了磷灰石的生长，具有较高的细胞活力和血液相容性。然而，在 1400°C 下烧结的样品具有最大的硬度。因此，从山羊骨中提取的羟基磷灰石可以在生物医学工程中找到更好的应用，类似于现有的人造合成材料。
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