Venetian Institute of Molecular Medicine, Padova, Italy.
Research Center for Child Mental Development, University of Fukui, Fukui, Japan.
Adv Exp Med Biol. 2019;1118:63-70. doi: 10.1007/978-3-030-05542-4_3.
Mental disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ), are generally characterized by a combination of abnormal thoughts, perceptions, emotions, behavior, and relationships with others. Multiple risk factors incorporating genetic and environmental susceptibility are associated with development of these disorders. Mitochondria have a central role in the energy metabolism, and the literature suggests energy metabolism abnormalities are widespread in the brains of subjects with MDD, BPD, and SZ. Numerous studies have shown altered expressions of mitochondria-related genes in these mental disorders. In addition, environmental factors for these disorders, such as stresses, have been suggested to induce mitochondrial abnormalities. Moreover, animal studies have suggested that interactions of altered expression of mitochondria-related genes and environmental factors might be involved in mental disorders. Further investigations into interactions of mitochondrial abnormalities with environmental factors are required to elucidate of the pathogenesis of these mental disorders.
精神障碍，如重度抑郁症（MDD）、双相情感障碍（BD）和精神分裂症（SZ），通常以异常的思维、感知、情绪、行为以及与他人的关系为特征。多种遗传和环境易感性的风险因素与这些障碍的发展有关。线粒体在能量代谢中起着核心作用，文献表明，在 MDD、BPD 和 SZ 患者的大脑中，能量代谢异常广泛存在。许多研究表明，这些精神障碍中线粒体相关基因的表达发生了改变。此外，这些障碍的环境因素，如压力，被认为会导致线粒体异常。此外，动物研究表明，线粒体相关基因表达改变和环境因素之间的相互作用可能与精神障碍有关。需要进一步研究线粒体异常与环境因素的相互作用，以阐明这些精神障碍的发病机制。
