Smirnov A V
Arkh Patol. 1988;50(12):17-24.
Immunofluorescent examination of extracellular matrix of 5 fibrosarcomas showed the matrix to contain fibronectin and collagen type I, III, V. Fibrosarcoma matrix is characterized by the absence of collagen type IV and collagen type III predominance over type I differentiating this tumor from synovial sarcoma, neurogenic sarcoma, dermatofibrosarcoma protuberans, malignant fibrous histiocytoma. Their matrices showed the presence of type IV collagen, equal proportion of interstitial collagens or collagen type I predominance over type III typical for synovial sarcoma. The findings can be employed in practical morphologic diagnosis of soft tissue tumors.
对5例纤维肉瘤细胞外基质进行免疫荧光检查，结果显示基质中含有纤连蛋白以及I、III、V型胶原。纤维肉瘤基质的特点是缺乏IV型胶原，且III型胶原占主导地位，I型胶原较少，这使其与滑膜肉瘤、神经源性肉瘤、隆突性皮肤纤维肉瘤、恶性纤维组织细胞瘤有所区别。这些肿瘤的基质显示存在IV型胶原，间质胶原比例相等或I型胶原占主导地位，这是滑膜肉瘤的典型特征。这些发现可用于软组织肿瘤的实际形态学诊断。
