Smirnov A V
Arkh Patol. 1991;53(1):40-7.
The distribution of type I, III, IV and V collagen and fibronectin in schwannomas and neurofibromas showed the similarity in the extracellular matrix structure of both tumours. Both the components of the interstitial connective tissue (collagen of I, III, V types and fibronectin) and component of basal membrane (the IV type collagen) are found in the fibrillar matrix of these two tumours. It is shown for the first time that matrix of rhythmical structures of schwannoma contains the collagen of type IV and fibronectin while the interstitial collagen of types I, III and V is absent. The application of the results obtained for the differential diagnosis of fibrous and neurogenic tumours is discussed.
I型、III型、IV型和V型胶原蛋白以及纤连蛋白在神经鞘瘤和神经纤维瘤中的分布表明，这两种肿瘤的细胞外基质结构相似。在这两种肿瘤的纤维状基质中均发现了间质结缔组织成分（I型、III型、V型胶原蛋白和纤连蛋白）以及基底膜成分（IV型胶原蛋白）。首次表明，神经鞘瘤节律性结构的基质中含有IV型胶原蛋白和纤连蛋白，而I型、III型和V型间质胶原蛋白缺失。讨论了所获结果在纤维性肿瘤和神经源性肿瘤鉴别诊断中的应用。
