Nanaev A K, Ermilova V D, Shekhonin B V, Domogatskiĭ S P, Idel'son G L
Arkh Patol. 1986;48(12):47-52.
Fibronectin and collagen I, III, IV, V distribution in preexisting and newly formed connective tissue of fibroadenomas and leaf-like human breast tumour was studied by the immunofluorescent method. Extracellular matrix of a newly formed connective tissue was characterized by the predominance of collagen type III, the presence of collagen type IV, a high content of fibronectin in a leaf-like tumour. Such characteristics of the extracellular matrix structure in benign tumours are interpreted as a manifestation of desmoplasia.
采用免疫荧光法研究了纤维连接蛋白和I、III、IV、V型胶原蛋白在纤维腺瘤和叶状乳腺肿瘤的原有及新形成的结缔组织中的分布。新形成的结缔组织的细胞外基质以III型胶原蛋白占优势、存在IV型胶原蛋白以及叶状肿瘤中纤维连接蛋白含量高为特征。良性肿瘤中细胞外基质结构的这些特征被解释为促结缔组织增生的表现。
