Van Kroonenburgh M J, Pauwels E K
Department of Diagnostic Radiology, University Hospital Leiden, The Netherlands.
Nucl Med Commun. 1988 Nov;9(11):919-30. doi: 10.1097/00006231-198811000-00009.
An overview of the literature is presented concerning the formation, detection, incidence and effect of the human immunoglobulin response on immunoscintigraphy. The following conclusions are drawn. The production of human anti-mouse antibodies (HAMAs) is associated with a diminished therapeutic response; adequate prevention of HAMA production is not yet possible; high HAMA titres give rise to rapid clearance of MoAb into the liver and marked reduction of tumour uptake which results in reduced image quality on immunoscintigraphy; alteration of antibody biodistribution is likely to be related to the in vivo formation of antibody-antibody complexes which could interfere with image quality when sequential imaging is carried out.
本文综述了有关人免疫球蛋白反应在免疫闪烁成像中的形成、检测、发生率及影响的文献。得出以下结论。人抗鼠抗体（HAMAs）的产生与治疗反应减弱有关；目前尚无法充分预防HAMAs的产生；高滴度的HAMAs会导致单克隆抗体迅速被肝脏清除，肿瘤摄取显著减少，从而导致免疫闪烁成像的图像质量下降；抗体生物分布的改变可能与抗体-抗体复合物在体内的形成有关，当进行序列成像时，这可能会干扰图像质量。
