Hoover-Plow J, Farrer C, Presley D, Crapo P, Salamon P
School of Family Studies and Consumer Sciences, Department of Mathematical Sciences, San Diego State University.
Prog Food Nutr Sci. 1988;12(3):279-92.
Due to the importance of diet in the management of noninsulin dependent diabetes, we are interested in constructing a model to study the glycemic response to different foods in normal and diabetic subjects. In this study, serum glucose and insulin values from individual normal subjects (Diab. 26, 1178) following the ingestion of different foods (corn, rice, bread, potato) high in complex carbohydrate were analyzed to determine glucose infusion rates (J) into the blood from the gut as a function of time following the ingestion of the food item. A Modular Modeling Program was designed to allow selection of data, curve fit, model, and tuning of parameters. The two models used were from Ackerman et al (Phys. Med. Biol. 9, 203) and the minimal model (VI) from Bergman and Cobelli (Fed. Proc. 39,110). The models were modified so that glucose and insulin values were used as input and J was the output. There was a good correspondence between the shape of the J curves predicted by the two models. While the J curves resembled serum glucose curves, they generally reached a peak earlier and declined more rapidly. Two peaks occurred in the J curves for bread, corn and rice. The second peaks may correspond to a delay in the release of glucose during digestion. The resulting infusion rate characterization of these foodstuffs maybe useful for modeling responses in diabetic patients with normal gut function but with impaired peripheral glucose utilization and in detecting abnormal gut function.
由于饮食在非胰岛素依赖型糖尿病管理中的重要性，我们有兴趣构建一个模型来研究正常和糖尿病受试者对不同食物的血糖反应。在本研究中，分析了个体正常受试者（糖尿病26例，1178例）在摄入富含复合碳水化合物的不同食物（玉米、大米、面包、土豆）后血清葡萄糖和胰岛素值，以确定从肠道进入血液的葡萄糖输注速率（J）作为摄入食物后时间的函数。设计了一个模块化建模程序，以允许选择数据、曲线拟合、模型和参数调整。使用的两个模型来自阿克曼等人（《物理医学与生物学》9，203）以及伯格曼和科贝利的最小模型（VI）（《联邦程序》39，110）。对模型进行了修改，以便将葡萄糖和胰岛素值用作输入，J用作输出。两个模型预测的J曲线形状之间有很好的对应关系。虽然J曲线类似于血清葡萄糖曲线，但它们通常更早达到峰值且下降更快。面包、玉米和大米的J曲线出现了两个峰值。第二个峰值可能对应于消化过程中葡萄糖释放的延迟。这些食物的输注速率特征可能有助于对肠道功能正常但外周葡萄糖利用受损的糖尿病患者的反应进行建模，以及检测异常肠道功能。
