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UTX Mutations in Human Cancer.
Cancer Cell. 2019 Feb 11;35(2):168-176. doi: 10.1016/j.ccell.2019.01.001.
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Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization.
Oncogene. 2020 Apr;39(16):3322-3335. doi: 10.1038/s41388-020-1218-3. Epub 2020 Feb 18.
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Lysine Demethylase KDM6A in Differentiation, Development, and Cancer.
Mol Cell Biol. 2020 Sep 28;40(20). doi: 10.1128/MCB.00341-20.
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Increased expression of the histone H3 lysine 4 methyltransferase MLL4 and the histone H3 lysine 27 demethylase UTX prolonging the overall survival of patients with glioblastoma and a methylated MGMT promoter.
J Neurosurg. 2017 May;126(5):1461-1471. doi: 10.3171/2016.4.JNS1652. Epub 2016 Jul 1.
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The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Exp Mol Med. 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6.
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The H3K27me3 demethylase UTX in normal development and disease.
Epigenetics. 2014 May;9(5):658-68. doi: 10.4161/epi.28298. Epub 2014 Feb 21.
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The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation.
J Biol Chem. 2015 Oct 9;290(41):25151-63. doi: 10.1074/jbc.M115.662650. Epub 2015 Aug 25.
8
UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells.
Cancer Res. 2014 Mar 15;74(6):1705-17. doi: 10.1158/0008-5472.CAN-13-1896. Epub 2014 Feb 3.
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Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.
Nat Med. 2018 Jun;24(6):758-769. doi: 10.1038/s41591-018-0034-6. Epub 2018 May 21.
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The histone demethylase UTX/KDM6A in cancer: Progress and puzzles.
Int J Cancer. 2019 Aug 1;145(3):614-620. doi: 10.1002/ijc.32116. Epub 2019 Jan 28.
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KDM6A downregulation promotes tumor-prone cytokines expression in cancer-associated fibroblasts by activating enhancers.
Cell Death Dis. 2025 Jul 14;16(1):523. doi: 10.1038/s41419-025-07818-3.
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Phase Separation in Chromatin Organization and Human Diseases.
Int J Mol Sci. 2025 May 28;26(11):5156. doi: 10.3390/ijms26115156.
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UTX Responds to Nanotopography to Suppress Macrophage Inflammatory Response by Remodeling H3K27me3 Modification.
Adv Sci (Weinh). 2025 Aug;12(29):e05723. doi: 10.1002/advs.202505723. Epub 2025 May 19.
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UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia.
Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2422971122. doi: 10.1073/pnas.2422971122. Epub 2025 May 15.
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Harnessing the Deubiquitinase USP1 for Targeted Protein Stabilization.
J Am Chem Soc. 2025 Apr 30;147(17):14564-14573. doi: 10.1021/jacs.5c01662. Epub 2025 Apr 19.
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A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells.
Cell Rep. 2025 Jan 28;44(1):115192. doi: 10.1016/j.celrep.2024.115192. Epub 2025 Jan 11.
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Epigenetic Modifiers: Exploring the Roles of Histone Methyltransferases and Demethylases in Cancer and Neurodegeneration.
Biology (Basel). 2024 Dec 3;13(12):1008. doi: 10.3390/biology13121008.
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Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications.
Signal Transduct Target Ther. 2024 Nov 18;9(1):305. doi: 10.1038/s41392-024-02013-w.
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Neuroendocrine transdifferentiation in human cancer: molecular mechanisms and therapeutic targets.
MedComm (2020). 2024 Oct 4;5(10):e761. doi: 10.1002/mco2.761. eCollection 2024 Oct.
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Sex chromosome-encoded protein homologs: current progress and open questions.
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本文引用的文献
1
UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma.
Nat Commun. 2018 Jul 13;9(1):2720. doi: 10.1038/s41467-018-05084-w.
2
Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.
Nat Med. 2018 Jun;24(6):758-769. doi: 10.1038/s41591-018-0034-6. Epub 2018 May 21.
3
Enhancer Logic and Mechanics in Development and Disease.
Trends Cell Biol. 2018 Aug;28(8):608-630. doi: 10.1016/j.tcb.2018.04.003. Epub 2018 May 11.
4
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis.
Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3978-E3986. doi: 10.1073/pnas.1716589115. Epub 2018 Apr 9.
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Comprehensive Characterization of Cancer Driver Genes and Mutations.
Cell. 2018 Apr 5;173(2):371-385.e18. doi: 10.1016/j.cell.2018.02.060.
6
Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors.
Cancer Cell. 2018 Mar 12;33(3):512-526.e8. doi: 10.1016/j.ccell.2018.02.003.
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A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer.
Oncogene. 2018 Apr;37(14):1911-1925. doi: 10.1038/s41388-017-0099-6. Epub 2018 Jan 25.
8
UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.
Cell Rep. 2017 Oct 17;21(3):628-640. doi: 10.1016/j.celrep.2017.09.078.
9
Genome Regulation by Polycomb and Trithorax: 70 Years and Counting.
Cell. 2017 Sep 21;171(1):34-57. doi: 10.1016/j.cell.2017.08.002.
10
A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription.
Mol Cell. 2017 Jul 20;67(2):308-321.e6. doi: 10.1016/j.molcel.2017.06.028.
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