Jia Hengji, Zhang He, Mo Dingqiang, Xie Bo, Qiao Hongdou, Chen Tao, Song Haoyue, Xu Xinxin, Yang Sheng
College of Stomatology, Chongqing Medical University, Chongqing, China.
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, China.
Adv Sci (Weinh). 2025 Aug;12(29):e05723. doi: 10.1002/advs.202505723. Epub 2025 May 19.
Peri-implantitis is the leading cause of implant failure, primarily due to weak defense at the implant-soft tissue interface, which disrupts the local immune microenvironment. As an integral part of this microenvironment, the implant-tissue interface plays a critical role in shaping immune cell function. Thus, engineering the surface topography of implants has emerged as a novel strategy for sustained immunomodulation following implantation. This study investigated the mechanical regulation of macrophage function by nanopatterned topographies. Titanium nanotubes (TNTs) surfaces reduce the expression of phosphorylated myosin light chain (pMLC) and promote the retention of the UTX histone methyltransferase in the nucleus. This process attenuates the enrichment of the repressive H3K27me3 histone marker at the Abca1 gene locus, increasing Abca1 expression and suppressing inflammation. This study reveals the mechanosensitivity of UTX and provides a new target for the development of therapeutic strategies that integrate mechanical signaling and immune modulation.
种植体周围炎是种植体失败的主要原因，主要是由于种植体与软组织界面的防御能力较弱，这会破坏局部免疫微环境。作为这种微环境的一个组成部分，种植体与组织界面在塑造免疫细胞功能方面起着关键作用。因此，设计种植体的表面形貌已成为植入后持续免疫调节的一种新策略。本研究调查了纳米图案形貌对巨噬细胞功能的机械调节作用。钛纳米管（TNTs）表面可降低磷酸化肌球蛋白轻链（pMLC）的表达，并促进UTX组蛋白甲基转移酶在细胞核中的保留。这一过程减弱了抑制性H3K27me3组蛋白标记物在Abca1基因位点的富集，增加了Abca1的表达并抑制了炎症。本研究揭示了UTX的机械敏感性，并为整合机械信号和免疫调节的治疗策略的开发提供了新的靶点。
