Division of Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Center for Lipid Metabolomics, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
BMJ Open. 2019 Feb 11;9(2):e023647. doi: 10.1136/bmjopen-2018-023647.
Premature myocardial infarction (MI) generally refers to MI in men ≤55 years or women ≤65 years. Premature MI is a major contributor to cardiovascular disease (CVD), which claimed 17.6 million lives globally in 2016. Reducing premature MI and CVD is a key priority for all nations; however, there is sparse synthesis of information on risk factors associated with premature MI. To address this knowledge gap, we are conducting a systematic review to describe the association between risk factors (demographics, lifestyle factors and biomarkers) and premature MI.
The following databases were searched from inception to June 2018: CENTRAL, CINAHL, Clinical Trials, EMBASE and MEDLINE. We will include original research articles (case-control, cohort and cross-sectional studies) that report a quantitative relationship between at least one risk factor and premature MI. Two investigators will use predetermined selection criteria and independently screen articles based on title and abstract (primary screening). Articles that meet selection criteria will undergo full-text screening based on criteria used for primary screening (secondary screening). Data will be extracted using predetermined data extraction forms. The Newcastle-Ottawa Scale for case-control and cohort studies will be used to evaluate the risk of bias and will be adapted for cross-sectional studies. Whenever feasible, data will be summarised into a random-effects meta-analysis.
To our knowledge, this will be the first study to synthesise results on the relationship between risk factors and premature MI. These findings will inform healthcare providers on factors associated with risk of premature MI and potentially improve primary prevention efforts by guiding development of interventions. These findings will be summarised and presented at conferences and through publication in a peer-reviewed journal.
CRD42018076862.
过早性心肌梗死（MI）通常是指男性≤55 岁或女性≤65 岁的 MI。过早性 MI 是心血管疾病（CVD）的主要致病因素，2016 年，全球有 1760 万人死于 CVD。减少过早性 MI 和 CVD 是所有国家的重点优先事项；然而，关于与过早性 MI 相关的风险因素的信息综合很少。为了解决这一知识空白，我们正在进行一项系统评价，以描述风险因素（人口统计学、生活方式因素和生物标志物）与过早性 MI 之间的关联。
从开始到 2018 年 6 月，我们搜索了以下数据库：CENTRAL、CINAHL、ClinicalTrials、EMBASE 和 MEDLINE。我们将纳入原始研究文章（病例对照、队列和横断面研究），这些文章报告了至少一个风险因素与过早性 MI 之间的定量关系。两名研究人员将使用预定的选择标准，根据标题和摘要（初步筛选）独立筛选文章。符合选择标准的文章将根据初步筛选使用的标准进行全文筛选（二次筛选）。使用预定的数据提取表格提取数据。将使用纽卡斯尔-渥太华量表对病例对照和队列研究进行风险评估，并针对横断面研究进行调整。只要可行，数据将以随机效应荟萃分析进行总结。
据我们所知，这将是第一项综合研究风险因素与过早性 MI 之间关系的研究。这些发现将为医疗保健提供者提供与过早性 MI 风险相关的因素，并通过指导干预措施的制定，有可能改善初级预防工作。这些发现将在会议上总结和介绍，并通过在同行评议期刊上发表来传播。
PROSPERO 注册号：CRD42018076862。
