化学诱导单域抗体同源二聚化的结构基础。
Structural basis for chemically-induced homodimerization of a single domain antibody.
机构信息
Centre de Biochimie Structurale, CNRS UMR5048, INSERM U1054, Université de Montpellier, 29 rue de Navacelles, 34090, Montpellier, France.
出版信息
Sci Rep. 2019 Feb 12;9(1):1840. doi: 10.1038/s41598-019-38752-y.
Abstract
Chemically-induced dimerization (CID) systems are essential tools to interrogate and control biological systems. AcVHH is a single domain antibody homo-dimerizing upon caffeine binding. AcVHH has a strong potential for clinical applications through caffeine-mediated in vivo control of therapeutic gene networks. Here we provide the structural basis for caffeine-induced homo-dimerization of acVHH.
摘要
化学诱导二聚（CID）系统是研究和控制生物系统的重要工具。AcVHH 是一种单域抗体，在咖啡因结合后会发生同源二聚化。通过咖啡因介导的治疗性基因网络的体内控制，AcVHH 具有很强的临床应用潜力。本文提供了 AcVHH 咖啡因诱导同源二聚化的结构基础。
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