Zheng Can-Can, Hu Hui-Fang, Hong Pan, Zhang Qi-Hua, Xu Wen Wen, He Qing-Yu, Li Bin
Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University Guangzhou 510632, China.
Institute of Biomedicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic Medicine, Jinan University Guangzhou 510632, China.
Am J Cancer Res. 2019 Jan 1;9(1):186-197. eCollection 2019.
Integrin-linked kinase (ILK), which is an ankyrin repeat-containing serine/threonine protein kinase, interacts with integrin β1 and the β3 cytoplasmic domain and phosphorylates integrin β1. ILK has multiple functions in cells, such as cell-extracellular matrix interactions, cell cycle, apoptosis, cell proliferation and cell motility, which are associated with the interacting partners of ILK and downstream signaling pathways. Upregulation of ILK is frequently observed in cancer tissues compared to corresponding normal tissues. Emerging evidence has demonstrated that ILK plays an important role in biological processes associated with tumorigenesis, including cancer cell proliferation, angiogenesis, metastasis, and drug resistance. Furthermore, inhibition of ILK expression and activity using siRNA or chemical inhibitors has shown a significant suppressive effect on cancer development and progression, implicating the potential of ILK as a target for cancer treatment. In this review, we summarized the functional role of ILK in tumorigenesis, with the expectation that targeting ILK could provide more evidence for cancer therapy.
整合素连接激酶（ILK）是一种含有锚蛋白重复序列的丝氨酸/苏氨酸蛋白激酶，它与整合素β1和β3细胞质结构域相互作用，并使整合素β1磷酸化。ILK在细胞中具有多种功能，如细胞与细胞外基质的相互作用、细胞周期、细胞凋亡、细胞增殖和细胞运动，这些功能与ILK的相互作用伙伴和下游信号通路有关。与相应的正常组织相比，在癌组织中经常观察到ILK的上调。新出现的证据表明，ILK在与肿瘤发生相关的生物学过程中起重要作用，包括癌细胞增殖、血管生成、转移和耐药性。此外，使用小干扰RNA（siRNA）或化学抑制剂抑制ILK的表达和活性已显示出对癌症发展和进展的显著抑制作用，这表明ILK作为癌症治疗靶点的潜力。在本综述中，我们总结了ILK在肿瘤发生中的功能作用，期望靶向ILK可为癌症治疗提供更多证据。
