Ferreira Cristiana, Oliveira Ana, Furtado Antonia, Rocha Natividade, Ribeiro José Almeida
Serviço de Imunoalergologia, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.
Serviço de Dermatologia, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.
Eur J Case Rep Intern Med. 2018 Mar 21;5(3):000724. doi: 10.12890/2018_000724. eCollection 2018.
Little has been documented about hypersensitivity reactions caused by treatment with rivaroxaban. This paper reports a bullous pemphigoid-like skin eruption that occurred in a 76-year-old female patient during rivaroxaban treatment. This case highlights the vigilance required by healthcare workers in recognising potential adverse effects of newly marketed drugs and in making medication changes when necessary. A bullous pemphigoid-like eruption due to treatment with rivaroxaban has not, to the best of the Authors' knowledge, been reported previously in the literature.
Rivaroxaban can cause a bullous eruption apparently similar to epithelial toxic necrolysis (or to Stevens-Johnson syndrome).There is an apparent similarity between skin adverse events caused by the different anticoagulants.The anticoagulant responsible for the skin side-effects can be identified on clinical grounds by the correct differential diagnosis.
关于利伐沙班治疗引起的过敏反应，文献记载较少。本文报告了一名76岁女性患者在接受利伐沙班治疗期间出现的大疱性类天疱疮样皮肤疹。该病例强调了医护人员在识别新上市药物潜在不良反应以及在必要时进行药物调整方面所需的警惕性。据作者所知，利伐沙班治疗引起的大疱性类天疱疮样皮疹此前在文献中尚未有报道。
利伐沙班可引起明显类似于上皮毒性坏死松解症（或史蒂文斯-约翰逊综合征）的大疱性皮疹。不同抗凝剂引起的皮肤不良事件之间存在明显相似性。通过正确的鉴别诊断，可根据临床依据确定导致皮肤副作用的抗凝剂。
