膀胱内注射黏菌素治疗尿路感染
Intra-Vesical Colistin for Urinary Tract Infections.
作者信息
Assis Rui Encarnado, Coelho Inês, Real André, França Luís, Araújo Ana, Pereira Tiago, Catorze Nuno
机构信息
Intensive Care Unit, Centro Hospitalar do Médio Tejo, Abrantes, Portugal.
出版信息
Eur J Case Rep Intern Med. 2019 Jan 21;6(1):000996. doi: 10.12890/2019_000996. eCollection 2019.
Abstract
UNLABELLED
The numbers of multiple drug-resistant Gram-negative bacterial infections are rising worldwide. The threat is increased by the lack of new antibiotics, so clinicians are turning to older drugs previously abandoned due to their recognized toxicity, such as colistin. However, the need to avoid kidney toxicity from colistin has led to its topical use. We present the case of a patient with type I cardiorenal syndrome with cystitis due to multiple drug-resistant who was successfully treated with intravesical instillation of colistin.
LEARNING POINTS
The case report is one of the few in the literature on the intravesical instillation of colistin to address lower urinary tract infection.Isolated intravesical colistin instillation was effective in a patient with anuria.
摘要
未标注
全球范围内多重耐药革兰氏阴性菌感染的数量正在上升。由于缺乏新的抗生素，这种威胁加剧，因此临床医生开始使用因毒性已被公认而此前被弃用的老药，如黏菌素。然而，为避免黏菌素导致肾毒性，人们开始采用其局部用药方式。我们报告一例患有I型心肾综合征并因多重耐药菌引起膀胱炎的患者，经膀胱内灌注黏菌素成功治愈。
学习要点
该病例报告是文献中为数不多的关于膀胱内灌注黏菌素治疗下尿路感染的案例之一。单独膀胱内灌注黏菌素对无尿患者有效。
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本文引用的文献
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Curr Urol Rep. 2018 Aug 9;19(10):78. doi: 10.1007/s11934-018-0834-8.
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Epidemiology of antibiotic resistance in Pseudomonas aeruginosa. Implications for empiric and definitive therapy.铜绿假单胞菌抗生素耐药性的流行病学。对经验性和确定性治疗的影响。
Rev Esp Quimioter. 2017 Sep;30 Suppl 1:8-12.
3
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