膀胱内注射庆大霉素：间歇性导尿的神经源性膀胱患者治疗及预防复发性尿路感染和耐药菌的一种选择。
Intravesical Gentamicin: An Option for Therapy and Prophylaxis against Recurrent UTIs and Resistant Bacteria in Neurogenic Bladder Patients on Intermittent Catheterization.
作者信息
Andretta Elena, Longo Raffaele, Balladelli Massimo, Sgarabotto Camilla, Sgarabotto Dino
机构信息
Urology Department, Dolo Hospital, 30031 Venice, Italy.
Microbiology Department, Dolo Hospital, 30031 Venice, Italy.
出版信息
Antibiotics (Basel). 2022 Sep 30;11(10):1335. doi: 10.3390/antibiotics11101335.
Abstract
This is a retrospective study of our experience with Gentamicin intravesical instillation as therapy and prophylaxis in patients with lower urinary tract infections (UTIs) undergoing clean intermittent catheterization because of a neurogenic bladder. It is an alternative therapy when all other systemic treatments have failed as it is still an off-label prescription.
摘要
这是一项回顾性研究，总结了我们在因神经源性膀胱而接受清洁间歇性导尿的下尿路感染（UTI）患者中，使用庆大霉素膀胱内灌注进行治疗和预防的经验。当所有其他全身治疗均失败时，这是一种替代疗法，因为它仍然属于非适应证用药。
相似文献
1
Intravesical Gentamicin: An Option for Therapy and Prophylaxis against Recurrent UTIs and Resistant Bacteria in Neurogenic Bladder Patients on Intermittent Catheterization.膀胱内注射庆大霉素：间歇性导尿的神经源性膀胱患者治疗及预防复发性尿路感染和耐药菌的一种选择。
Antibiotics (Basel). 2022 Sep 30;11(10):1335. doi: 10.3390/antibiotics11101335.
2
Neomycin-polymyxin or gentamicin bladder instillations decrease symptomatic urinary tract infections in neurogenic bladder patients on clean intermittent catheterization.新霉素-多粘菌素或庆大霉素膀胱灌注可减少清洁间歇性导尿的神经源性膀胱患者的症状性尿路感染。
J Pediatr Urol. 2019 Apr;15(2):178.e1-178.e7. doi: 10.1016/j.jpurol.2018.12.001. Epub 2018 Dec 12.
3
Intravesical gentamicin instillation in the prevention of recurrent urinary tract infections in children with neurogenic bladder- a single-center retrospective observational study.膀胱内灌注庆大霉素预防神经源性膀胱患儿复发性尿路感染——一项单中心回顾性观察研究
J Pediatr Urol. 2023 Feb;19(1):64.e1-64.e7. doi: 10.1016/j.jpurol.2022.09.001. Epub 2022 Sep 23.
4
Bladder irrigation with povidone-iodine prevent recurrent urinary tract infections in neurogenic bladder patients on clean intermittent catheterization.聚维酮碘膀胱冲洗预防清洁间歇性导尿的神经原性膀胱患者复发性尿路感染。
Neurourol Urodyn. 2021 Feb;40(2):672-679. doi: 10.1002/nau.24607. Epub 2021 Jan 21.
5
Intravesical gentamicin instillation for the treatment and prevention of urinary tract infections in complex paediatric urology patients: evidence for safety and efficacy.膀胱内灌注庆大霉素用于治疗和预防复杂儿科泌尿外科患者的尿路感染：安全性和有效性证据
J Pediatr Urol. 2021 Feb;17(1):65.e1-65.e11. doi: 10.1016/j.jpurol.2020.08.007. Epub 2020 Aug 19.
6
Bladder instillation for urinary tract infection prevention in neurogenic bladder patients practicing clean intermittent catheterization: A systematic review.清洁间歇性导尿的神经源性膀胱患者预防尿路感染的膀胱灌注：一项系统评价
Urologia. 2022 May;89(2):261-267. doi: 10.1177/03915603211049883. Epub 2021 Oct 6.
7
Intravesical gentamicin for recurrent urinary tract infection in patients with intermittent bladder catheterisation.经尿道给予庆大霉素治疗间歇性膀胱导尿患者复发性尿路感染。
Int J Antimicrob Agents. 2010 Dec;36(6):485-90. doi: 10.1016/j.ijantimicag.2010.05.005. Epub 2010 Jun 26.
8
Intravesical hyaluronic acid treatment in recurrent urinary tract infections in children with spina bifida and neurogenic bladder.膀胱内注射透明质酸治疗脊柱裂和神经源性膀胱患儿复发性尿路感染
J Pediatr Urol. 2020 Jun;16(3):366.e1-366.e5. doi: 10.1016/j.jpurol.2020.02.009. Epub 2020 Feb 22.
9
The use of intravesical gentamicin to treat recurrent urinary tract infections in lower urinary tract dysfunction.膀胱内使用庆大霉素治疗下尿路功能障碍中的复发性尿路感染。
Neurourol Urodyn. 2017 Nov;36(8):2109-2116. doi: 10.1002/nau.23250. Epub 2017 May 15.
10
Effectiveness and patient perspective on the use of intravesical gentamicin instillations to treat recurrent urinary tract infections in neurogenic lower urinary tract dysfunction.经尿道给予庆大霉素灌注治疗神经原性下尿路功能障碍患者复发性尿路感染的效果和患者观点。
Neurourol Urodyn. 2024 Nov;43(8):1916-1923. doi: 10.1002/nau.25513. Epub 2024 Jun 11.
引用本文的文献
1
The Effects of Gentamicin Intravesical Bladder Instillations on Decreasing Urinary Tract Infections After Spinal Cord Injury and Disease.庆大霉素膀胱内灌注对降低脊髓损伤和疾病后尿路感染的作用
Neurourol Urodyn. 2025 Apr;44(4):829-838. doi: 10.1002/nau.70037. Epub 2025 Mar 17.
2
Gentamicin loaded niosomes against intracellular uropathogenic Escherichia coli strains.负载庆大霉素的非离子表面活性剂囊泡对抗细胞内尿路致病性大肠杆菌菌株
Sci Rep. 2024 May 3;14(1):10196. doi: 10.1038/s41598-024-59144-x.
3
SWOT and Root Cause Analyses of Antimicrobial Resistance to Oral Antimicrobial Treatment of Cystitis.膀胱炎口服抗菌治疗的抗菌药物耐药性的SWOT分析和根本原因分析。
Antibiotics (Basel). 2024 Apr 4;13(4):328. doi: 10.3390/antibiotics13040328.
4
The urological evaluation and management of neurogenic bladder in children and adolescents-what every pediatric nephrologist needs to know.儿童和青少年神经源性膀胱的泌尿科评估和管理——每位儿科肾脏病学家都需要了解的知识。
Pediatr Nephrol. 2024 Feb;39(2):409-421. doi: 10.1007/s00467-023-06064-z. Epub 2023 Jul 31.
5
Unmet Needs in Complicated Urinary Tract Infections: Challenges, Recommendations, and Emerging Treatment Pathways.复杂尿路感染未满足的需求：挑战、建议及新出现的治疗途径
Infect Drug Resist. 2023 Mar 11;16:1391-1405. doi: 10.2147/IDR.S382617. eCollection 2023.
6
Is There Any Benefit to the Use of Antibiotics with Indwelling Catheters after Urologic Surgery in Adults.成人泌尿外科手术后留置导管使用抗生素有任何益处吗？
Antibiotics (Basel). 2023 Jan 12;12(1):156. doi: 10.3390/antibiotics12010156.
本文引用的文献
1
Efficacy of antimicrobial intravesical treatment for uncomplicated recurrent urinary tract infections: a systematic review.抗菌膀胱内治疗非复杂性复发性尿路感染的疗效：系统评价。
Int Urogynecol J. 2022 May;33(5):1125-1143. doi: 10.1007/s00192-021-05042-z. Epub 2022 Jan 4.
2
Proximate and ultimate causes of the bactericidal action of antibiotics.抗生素杀菌作用的近因和远因。
Nat Rev Microbiol. 2021 Feb;19(2):123-132. doi: 10.1038/s41579-020-00443-1. Epub 2020 Oct 6.
3
Intravesical Antibiotic Administration in the Treatment of Recurrent Urinary Tract Infections: Promising Results From a Case Series.膀胱内给予抗生素治疗复发性尿路感染：一项病例系列研究的 promising 结果。
注：这里“promising”直译为“有希望的”，结合语境意译为“令人鼓舞的”等更通顺，但按要求保留原文未翻译。
Female Pelvic Med Reconstr Surg. 2020 Feb;26(2):152-154. doi: 10.1097/SPV.0000000000000810.
4
Intra-Vesical Colistin for Urinary Tract Infections.膀胱内注射黏菌素治疗尿路感染
Eur J Case Rep Intern Med. 2019 Jan 21;6(1):000996. doi: 10.12890/2019_000996. eCollection 2019.
5
Neomycin-polymyxin or gentamicin bladder instillations decrease symptomatic urinary tract infections in neurogenic bladder patients on clean intermittent catheterization.新霉素-多粘菌素或庆大霉素膀胱灌注可减少清洁间歇性导尿的神经源性膀胱患者的症状性尿路感染。
J Pediatr Urol. 2019 Apr;15(2):178.e1-178.e7. doi: 10.1016/j.jpurol.2018.12.001. Epub 2018 Dec 12.
6
Intravesical Gentamicin Treatment for Recurrent Urinary Tract Infections Caused by Multidrug Resistant Bacteria.膀胱内庆大霉素治疗由多重耐药菌引起的复发性尿路感染。
J Urol. 2019 Mar;201(3):549-555. doi: 10.1016/j.juro.2018.10.004.
7
Use and Effectiveness of Antimicrobial Intravesical Treatment for Prophylaxis and Treatment of Recurrent Urinary Tract Infections (UTIs): a Systematic Review.抗菌膀胱内治疗预防和治疗复发性尿路感染（UTIs）的应用及有效性：一项系统评价
Curr Urol Rep. 2018 Aug 9;19(10):78. doi: 10.1007/s11934-018-0834-8.
8
Gentamicin bladder instillations decrease symptomatic urinary tract infections in neurogenic bladder patients on intermittent catheterization.庆大霉素膀胱灌注可减少间歇性导尿的神经源性膀胱患者的症状性尿路感染。
Can Urol Assoc J. 2017 Sep;11(9):E350-E354. doi: 10.5489/cuaj.4434.
9
Recurrent urinary tract infections in women.女性复发性尿路感染
Int Urogynecol J. 2015 Jun;26(6):795-804. doi: 10.1007/s00192-014-2569-5. Epub 2014 Nov 20.
10
Epidemiology and healthcare utilization of neurogenic bladder patients in a US claims database.美国索赔数据库中神经源性膀胱患者的流行病学和医疗保健利用情况。
Neurourol Urodyn. 2011 Mar;30(3):395-401. doi: 10.1002/nau.21003. Epub 2010 Sep 29.
Zotero 插件