Investigation of Therapeutic Efficacy of Intravesical Tigecycline Administration in Rats with Cystitis Induced by Extensively Drug-Resistant (XDR), Tigecycline-Sensitive Strain.

BACKGROUND

This study aimed to evaluate the therapeutic efficacy of intravesical tigecycline administration in a rat model of cystitis induced by a tigecycline-sensitive, extensively drug-resistant (XDR) strain.

METHODS

Thirty-six female Wistar albino rats were inoculated intravesically with XDR to induce cystitis. Twenty-four rats that developed infection were divided into four groups: untreated control, saline irrigation, low-dose tigecycline (6.25 mg/kg), and high-dose tigecycline (25 mg/kg). Microbiological clearance was assessed via urine cultures on days 3 and 5. Bladder tissues were analyzed histopathologically and for genotoxicity using the Comet assay.

RESULTS

On day 5, microbiological clearance was significantly higher in tigecycline-treated groups compared to controls ( = 0.028). Histopathology revealed significantly more inflammation in the high-dose tigecycline group ( = 0.029). Genotoxicity was observed in both tigecycline groups, independent of dose ( < 0.05).

CONCLUSIONS

Intravesical tigecycline demonstrated microbiological efficacy against XDR -induced cystitis. However, its inflammatory and genotoxic potential necessitates further preclinical evaluation.