Department of Physical Medicine and Rehabilitation, Cukurova University Faculty of Medicine, Adana, Turkey.
Rheumatol Int. 2019 May;39(5):781-791. doi: 10.1007/s00296-019-04251-6. Epub 2019 Feb 13.
Fibromyalgia is a multifaceted disease. The clinical picture of fibromyalgia covers numerous comorbidities. Each comorbidity stands as a distinct condition. However, common pathophysiologic factors are occupied in their background. Along with the genetic, environmental and neuro-hormonal factors, inflammation has been supposed to have role in the pathogenesis of fibromyalgia. The aim of the present article was to review the current literature regarding the potential role of inflammation in the pathogenesis and treatment of fibromyalgia. A literature search was conducted through PubMed/MEDLINE and Web of Science databases using relevant keywords. Recent evidence on this highly studied topic indicates that fibromyalgia has an immunological background. Cytokines/chemokines, lipid mediators, oxidative stress and several plasma-derived factors underlie the inflammatory state in fibromyalgia. There are potential new therapeutic options targeting inflammatory pathways in fibromyalgia patients. In conclusion, there is evidence to support the inflammation-driven pathways in the pathogenesis of fibromyalgia. However, further research is required to fully understand the network of inflammation and its possible role in diagnosis and/or treatment of fibromyalgia.
纤维肌痛是一种多方面的疾病。纤维肌痛的临床表现涵盖了众多共病。每种共病都代表一种独特的病症。然而，共同的病理生理因素在其背景中占据主导地位。除了遗传、环境和神经激素因素外，炎症也被认为在纤维肌痛的发病机制中起作用。本文旨在回顾关于炎症在纤维肌痛发病机制和治疗中的潜在作用的现有文献。通过使用相关关键词，在 PubMed/MEDLINE 和 Web of Science 数据库中进行了文献检索。关于这一高度研究课题的最新证据表明，纤维肌痛具有免疫学背景。细胞因子/趋化因子、脂质介质、氧化应激和几种血浆来源的因子是纤维肌痛中炎症状态的基础。针对纤维肌痛患者的炎症途径有潜在的新治疗选择。总之，有证据支持纤维肌痛发病机制中的炎症驱动途径。然而，需要进一步的研究来充分了解炎症网络及其在纤维肌痛的诊断和/或治疗中的可能作用。
