Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
J Neuroimmunol. 2012 Jan 18;242(1-2):33-8. doi: 10.1016/j.jneuroim.2011.10.013. Epub 2011 Nov 29.
Activation of glia cells resulting in intrathecal elevation of cytokines and chemokines has been hypothesized in chronic pain syndromes such as fibromyalgia. To our knowledge, this is the first study assessing intrathecal concentrations of pro-inflammatory substances in fibromyalgia. We report elevated cerebrospinal fluid and serum concentrations of interleukin-8, but not interleukin-1beta, in FM patients. This profile is in accordance with FM symptoms being mediated by sympathetic activity rather than dependent on prostaglandin associated mechanisms and supports the hypothesis of glia cell activation in response to pain mechanisms.
据推测，胶质细胞的激活会导致脊髓液中细胞因子和趋化因子的水平升高，这种现象与慢性疼痛综合征有关，如纤维肌痛症。据我们所知，这是首次评估纤维肌痛症患者脊髓液中促炎物质浓度的研究。我们报告称，纤维肌痛症患者的脑脊液和血清中白细胞介素-8 的浓度升高，而白细胞介素-1β的浓度没有升高。这种情况与纤维肌痛症的症状是由交感神经活动介导的，而不是依赖于前列腺素相关机制的症状相符，并且支持针对疼痛机制的胶质细胞激活的假说。
