Furer Victoria, Hazan Eyal, Mor Adi, Segal Michal, Katav Avi, Aloush Valerie, Elkayam Ori, George Jacob, Ablin Jacob N
Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Pain Res Manag. 2018 May 13;2018:7257681. doi: 10.1155/2018/7257681. eCollection 2018.
FMS patients demonstrate an altered profile of chemokines relative to healthy controls (HC). Eotaxin-2 is a potent chemoattractant distributed in a variety of tissues. The aim of the study was to compare serum levels of eotaxin-2 between FMS patients and HC and to examine a potential correlation between eotaxin-2 levels and clinical parameters of FMS. . 50 patients with FMS and 15 HC were recruited. Data on the severity of FMS symptoms and depression were collected. Serum levels of eotaxin-2 (ELISA) were determined in all participants. High-sensitive CRP (hs-CRP) was measured in the FMS group. . The FMS cohort included predominantly females (84%), mean age of 49, and mean disease duration of 6 years. FMS patients exhibited significantly higher eotaxin-2 levels (pg/ml) versus HC: 833 (±384) versus 622 (±149), =0.04. Mean hs-CRP level among FMS patients was 4.8 ± 6 mg/l, a value not indicative of acute inflammation. No correlation was found between eotaxin-2 and hs-CRP levels. No correlation was found between eotaxin-2 and severity measures of FMS or depression. . Eotaxin-2 does not appear to be a candidate for a disease activity biomarker in FMS. Further research is warranted into the role of this chemokine in the pathophysiology of the FMS.
与健康对照组（HC）相比，纤维肌痛（FMS）患者的趋化因子谱有所改变。嗜酸性粒细胞趋化因子-2是一种分布于多种组织中的强效化学引诱剂。本研究的目的是比较FMS患者和HC之间血清嗜酸性粒细胞趋化因子-2的水平，并研究嗜酸性粒细胞趋化因子-2水平与FMS临床参数之间的潜在相关性。招募了50例FMS患者和15例HC。收集了FMS症状严重程度和抑郁的数据。测定了所有参与者血清嗜酸性粒细胞趋化因子-2的水平（酶联免疫吸附测定法）。在FMS组中测量了高敏C反应蛋白（hs-CRP）。FMS队列主要包括女性（84%），平均年龄49岁，平均病程6年。与HC相比，FMS患者的嗜酸性粒细胞趋化因子-2水平（pg/ml）显著更高：833（±384）对622（±149），P = 0.04。FMS患者的平均hs-CRP水平为4.8±6mg/l，该值不表明存在急性炎症。未发现嗜酸性粒细胞趋化因子-2与hs-CRP水平之间存在相关性。未发现嗜酸性粒细胞趋化因子-2与FMS或抑郁的严重程度指标之间存在相关性。嗜酸性粒细胞趋化因子-2似乎不是FMS疾病活动生物标志物的候选物。有必要进一步研究这种趋化因子在FMS病理生理学中的作用。
