Cell Cycle Laboratory, The Francis Crick Institute, London, United Kingdom.
Laboratory of Yeast Genetics and Cell Biology, Rockefeller University, New York, United States of America.
PLoS Genet. 2019 Feb 13;15(2):e1007929. doi: 10.1371/journal.pgen.1007929. eCollection 2019 Feb.
Nuclear size correlates with cell size, but the mechanism by which this scaling is achieved is not known. Here we screen fission yeast gene deletion mutants to identify essential factors involved in this process. Our screen has identified 25 essential factors that alter nuclear size, and our analysis has implicated RNA processing and LINC complexes in nuclear size control. This study has revealed lower and more extreme higher nuclear size phenotypes and has identified global cellular processes and specific structural nuclear components important for nuclear size control.
核大小与细胞大小相关，但实现这种比例的机制尚不清楚。在这里，我们筛选裂殖酵母基因缺失突变体，以鉴定参与该过程的必需因子。我们的筛选已经确定了 25 个改变核大小的必需因子，我们的分析表明 RNA 处理和 LINC 复合物参与核大小的控制。本研究揭示了更低和更高的核大小表型，并确定了对核大小控制重要的全局细胞过程和特定的结构性核成分。
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