Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
PLoS Biol. 2019 Feb 13;17(2):e3000143. doi: 10.1371/journal.pbio.3000143. eCollection 2019 Feb.
p53 regulates the expression of hundreds of genes. Recent surprising observations indicate that no single protein-coding gene controls the tumor suppressor effects of p53. This raises the possibility that a subset of these genes, regulated by a p53-induced long noncoding RNA (lncRNA), could control p53's tumor suppressor function. We propose molecular mechanisms through which lncRNAs could regulate this subset of genes and hypothesize an exciting, direct role of lncRNAs in p53's genome stability maintenance function. Exploring these mechanisms could reveal lncRNAs as indispensable mediators of p53 and lay the foundation for understanding how other transcription factors could act via lncRNAs.
p53 调节数百个基因的表达。最近令人惊讶的观察结果表明，没有单个蛋白质编码基因控制 p53 的肿瘤抑制作用。这就提出了一种可能性，即这些基因中的一个亚组，受 p53 诱导的长非编码 RNA（lncRNA）调控，可能控制 p53 的肿瘤抑制功能。我们提出了 lncRNA 调控这组基因的分子机制，并假设 lncRNA 在 p53 的基因组稳定性维持功能中发挥着令人兴奋的直接作用。探索这些机制可以揭示 lncRNA 作为 p53 不可或缺的介质，并为理解其他转录因子如何通过 lncRNA 发挥作用奠定基础。
