Chaudhary Ritu, Lal Ashish
Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
Wiley Interdiscip Rev RNA. 2017 May;8(3). doi: 10.1002/wrna.1410. Epub 2016 Dec 19.
The tumor-suppressor protein p53 is activated in response to numerous cellular stresses including DNA damage. p53 functions primarily as a sequence-specific transcription factor that controls the expression of hundreds of protein-coding genes and noncoding RNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). While the role of protein-coding genes and miRNAs in mediating the effects of p53 has been extensively studied, the physiological function and molecular mechanisms by which p53-regulated lncRNAs act is beginning to be understood. In this review, we discuss recent studies on lncRNAs that are directly or indirectly regulated by p53 and how they contribute to the biological outcomes of p53 activation. WIREs RNA 2017, 8:e1410. doi: 10.1002/wrna.1410 For further resources related to this article, please visit the WIREs website.
肿瘤抑制蛋白p53会在包括DNA损伤在内的多种细胞应激反应中被激活。p53主要作为一种序列特异性转录因子发挥作用，它控制着数百种蛋白质编码基因以及非编码RNA的表达，这些非编码RNA包括微小RNA（miRNA）和长链非编码RNA（lncRNA）。虽然蛋白质编码基因和miRNA在介导p53效应方面的作用已得到广泛研究，但p53调控的lncRNA发挥作用的生理功能和分子机制才刚刚开始被了解。在这篇综述中，我们讨论了关于直接或间接受p53调控的lncRNA的最新研究，以及它们如何促成p53激活后的生物学结果。WIREs RNA 2017, 8:e1410. doi: 10.1002/wrna.1410 有关本文的更多资源，请访问WIREs网站。
