Lu Min, Wu Beirong, Qiao Rong, Gu Haoxiang, Din Ying, Dong Xiaoyan
Shanghai Jiao Tong University, Children’s Hospital of Shanghai (Jing An Branch), Department of Pulmonary Medicine, Shanghai, China
Shanghai Jiao Tong University, Children’s Hospital of Shanghai, Department of Outpatient, Shanghai, China
J Clin Res Pediatr Endocrinol. 2019 Sep 3;11(3):270-277. doi: 10.4274/jcrpe.galenos.2019.2018.0098. Epub 2019 Feb 14.
Studies have reported inconsistent results on the associations between lipids and insulin resistance (IR) and asthma. The purpose of this study was to examine the associations between abnormal serum lipid levels and homeostatic model assessment-IR (HOMA-IR) and the presence of current asthma in children and adolescents.
The United States National Health and Nutrition Examination Survey database from 1999 to 2012 was randomly searched for children (aged 3-11 years) and adolescents (aged 12-19 years) with and without asthma and with complete demographic and clinical data of interest. Logistic regression analyses were performed to examine associations between abnormal serum lipids, glucose and HOMA-IR and the current presence of asthma.
The data of 11,662 children (3 to 11 years of age) and 12,179 adolescents (12 to 19 years of age) were included in the analysis. The study group included 3,703 participants with asthma and 20,138 participants without asthma. The prevalence of self-reported current asthma was higher among participants aged between 3-11 years (52.9%) than among those aged between 12-19 years (50.7%). Multivariate analyses, after adjusting for sex, race, income-to-poverty ratio, low birth weight, prenatal maternal smoking, tobacco exposure, C-reactive protein level and body mass index Z-score, revealed no associations between elevated fasting plasma glucose, reduced high-density lipoprotein cholesterol, elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides and HOMA-IR and the presence of current asthma in children or adolescents.
In this cross-sectional study, no association was found between abnormal serum lipids or HOMA-IR and the presence of current asthma in children or adolescents.
关于脂质与胰岛素抵抗（IR）及哮喘之间的关联，研究报告的结果并不一致。本研究旨在探讨儿童和青少年血清脂质异常水平与稳态模型评估胰岛素抵抗（HOMA-IR）以及当前哮喘存在情况之间的关联。
随机检索1999年至2012年美国国家健康与营养检查调查数据库，纳入有和没有哮喘且具备完整相关人口统计学和临床数据的儿童（3至11岁）及青少年（12至19岁）。进行逻辑回归分析，以检验血清脂质异常、血糖和HOMA-IR与当前哮喘存在情况之间的关联。
分析纳入了11662名儿童（3至11岁）和12179名青少年（12至19岁）的数据。研究组包括3703名哮喘患者和20138名非哮喘患者。自我报告的当前哮喘患病率在3至11岁参与者中（52.9%）高于12至19岁参与者（50.7%）。在调整了性别、种族、收入与贫困比率、低出生体重、产前母亲吸烟、烟草暴露、C反应蛋白水平和体重指数Z评分后进行的多变量分析显示，空腹血糖升高、高密度脂蛋白胆固醇降低、低密度脂蛋白胆固醇升高、总胆固醇、甘油三酯和HOMA-IR与儿童或青少年当前哮喘的存在情况之间无关联。
在这项横断面研究中，未发现儿童或青少年血清脂质异常或HOMA-IR与当前哮喘的存在情况之间存在关联。
