Fan Yun, Zhang Chunlan, Bu Jin
State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 211166, Jiangsu, China.
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China.
Nutrients. 2017 Feb 3;9(2):104. doi: 10.3390/nu9020104.
The prevalence of obesity has increased at an alarming rate worldwide. Metallic elements are involved in the pathogenesis of obesity and related diseases. To date, whether environmental exposure to metallic elements has effects on obesity in children and adolescents is still unclear. The aim of the current study was to investigate the association of blood metallic elements with obesity in U.S. children and adolescents. This cross-sectional study was performed with 5404 children and adolescents (6-19 years, 2745 males and 2659 females) who participated in the US National Health and Nutrition Examination Survey 2011-2014. Blood lead, mercury, selenium, manganese, copper, and zinc, as well as biochemical parameters including triglyceride (TG), cholesterol, low-density lipoprotein (LDL), and homeostasis model assessment of insulin resistance (HOMA-IR) were assessed for all subjects. Multivariate logistic regression and linear regression were applied to assess associations of metallic elements and overweight, obesity status, and serum metabolites as distinct outcomes adjusted for age, gender, ethnicity, and the poverty income ratio. When stratified by age and sex, significant associations were found between the highest quartile of copper concentrations in blood with obesity status (OR = 9.27, 95% CI: 5.43, 15.82, < 0.001) and cholesterol (OR = 3.08, 95% CI: 1.43, 6.63, < 0.001). The highest concentrations of manganese in the blood was associated with obesity in those aged 6-19 years (OR = 2.29, 95% CI: 1.74, 3.02, < 0.001). Moreover, blood mercury and selenium showed positive relationships with cholesterol. Further, a negative association existed between blood zinc and obesity. The National Health and Nutrition Examination Survey data provide epidemiological evidence that blood metallic elements are positively associated with obesity in children and adolescents. However, the underlying mechanisms still need further exploration.
全球肥胖患病率正以惊人的速度上升。金属元素参与肥胖及相关疾病的发病机制。迄今为止，环境暴露于金属元素是否会影响儿童和青少年的肥胖状况仍不清楚。本研究的目的是调查美国儿童和青少年血液中金属元素与肥胖之间的关联。这项横断面研究对参与2011 - 2014年美国国家健康与营养检查调查的5404名儿童和青少年（6 - 19岁，2745名男性和2659名女性）进行。对所有受试者评估了血铅、汞、硒、锰、铜和锌，以及包括甘油三酯（TG）、胆固醇、低密度脂蛋白（LDL）和胰岛素抵抗稳态模型评估（HOMA - IR）在内的生化参数。应用多变量逻辑回归和线性回归来评估金属元素与超重、肥胖状态以及血清代谢物之间的关联，并将年龄、性别、种族和贫困收入比作为不同结果进行调整。按年龄和性别分层时，发现血液中铜浓度最高四分位数与肥胖状态（OR = 9.27，95% CI：5.43，15.82，P < 0.001）和胆固醇（OR = 3.08，95% CI：1.43，6.63，P < 0.001）之间存在显著关联。血液中锰的最高浓度与6 - 19岁人群的肥胖有关（OR = 2.29，95% CI：1.74，3.02，P < 0.001）。此外，血汞和硒与胆固醇呈正相关。此外，血锌与肥胖之间存在负相关关系。美国国家健康与营养检查调查数据提供了流行病学证据表明血液中的金属元素与儿童和青少年肥胖呈正相关。然而，其潜在机制仍需进一步探索。
